7-Dehydrocholesterol: A sterol shield against an iron sword

被引：3
作者：
Cui, Shaojie [1 ,2 ,3 ]
Ye, Jin [3 ]
机构：
[1] Huazhong Agr Univ, Coll Biomed & Hlth, Wuhan 430070, Hubei, Peoples R China
[2] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Hubei, Peoples R China
[3] Univ Texas Southwestern Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA
来源：
MOLECULAR CELL | 2024年 / 84卷 / 07期
基金：
美国国家卫生研究院;
关键词：
REDUCTASE;
D O I：
10.1016/j.molcel.2024.03.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Li et al. and Freitas et al. recently identified 7-dehydrocholesterol (7-DHC), a sterol produced through the cholesterol biosynthetic pathway, as a lipid-soluble antioxidant that protects cells from ferroptosis, a cell death pathway triggered by iron-catalyzed phospholipid peroxidation.
引用
收藏
页码：1183 / 1185
页数：3
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