Association of Cancer and Its Interaction with Conventional Risk Factors on Cardiovascular Disease Risk

被引：0

作者：

Suzuki, Yuta ^{[1
,2
]}

Kaneko, Hidehiro ^{[1
,3
]}

Okada, Akira ^{[4
]}

Matsuoka, Satoshi ^{[1
,5
]}

Kashiwabara, Kosuke ^{[6
]}

Fujiu, Katsuhito ^{[1
,3
]}

Michihata, Nobuaki ^{[7
]}

Jo, Taisuke ^{[7
]}

Takeda, Norifumi ^{[1
]}

Morita, Hiroyuki ^{[1
]}

Node, Koichi ^{[8
]}

Yasunaga, Hideo ^{[9
]}

Komuro, Issei ^{[1
,10
,11
]}

机构：

[1] Univ Tokyo, Dept Cardiovasc Med, Tokyo, Japan

[2] Natl Inst Publ Hlth, Ctr Outcomes Res & Econ Evaluat Hlth, Saitama, Japan

[3] Univ Tokyo, Dept Adv Cardiol, Tokyo, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Prevent Diabet & Lifestyle Related Dis, Tokyo, Japan

[5] New Tokyo Hosp, Dept Cardiol, Matsudo, Japan

[6] Univ Tokyo Hosp, Clin Res Promot Ctr, Tokyo, Japan

[7] Univ Tokyo, Dept Hlth Serv Res, Tokyo, Japan

[8] Saga Univ, Dept Cardiovasc Med, Saga, Japan

[9] Univ Tokyo, Sch Publ Hlth, Dept Clin Epidemiol & Hlth Econ, Tokyo, Japan

[10] Int Univ Hlth & Welf, Tokyo, Japan

[11] Univ Tokyo, Grad Sch Med, Dept Frontier Cardiovasc Sci, Tokyo, Japan

来源：

ONCOLOGY | 2024年 / 102卷 / 09期

关键词：

Cancer; Onco-cardiology; Preventive cardiology; Epidemiology; Cardiovascular disease risk; PREVENTION; STROKE;

D O I：

10.1159/000536449

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: We sought to examine the association of cancer history with the incidence of individual cardiovascular disease events and to clarify whether the history of cancer modifies the relationship between conventional cardiovascular risk factors and incident cardiovascular disease. Methods: This retrospective cohort study used the JMDC Claims Database, including 3,531,683 individuals. The primary endpoint was the composite cardiovascular disease outcome, which included myocardial infarction, angina pectoris, stroke, heart failure, and atrial fibrillation. Results: During a follow-up, 144,162 composite endpoints were recorded. Individuals with a history of cancer had a higher risk of developing composite cardiovascular disease events (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.22-1.29). The HRs for myocardial infarction, angina pectoris, stroke, heart failure, and atrial fibrillation were 1.11 (95% CI 0.98-1.27), 1.15 (95% CI 1.10-1.20), 1.11 (95% CI 1.05-1.18), 1.39 (95% CI 1.34-1.44), and 1.22 (95% CI 1.13-1.32), respectively. Individuals who required chemotherapy for cancer had a higher risk of developing cardiovascular disease. Although conventional risk factors (e.g., overweight/obesity, hypertension, and diabetes) were associated with incident composite cardiovascular disease even in individuals with a history of cancer, the total population-attributable fractions of conventional risk factors were less in individuals with a history of cancer. Conclusion: Individuals with a history of cancer (particularly those requiring chemotherapy) have a higher risk of cardiovascular disease. Traditional risk factors are important in the development of cardiovascular disease in individuals with and without a history of cancer. In individuals with a history of cancer, however, the total population-attributable fractions of conventional risk factors decreased.

引用

页码：775 / 784

页数：10