Long-read sequencing for brain tumors

被引：0

作者：

Shelton, William J. ^{[1
]}

Zandpazandi, Sara ^{[2
]}

Nix, J. Stephen ^{[3
]}

Gokden, Murat ^{[3
]}

Bauer, Michael ^{[4
]}

Ryan, Katie Rose ^{[5
]}

Wardell, Christopher P. ^{[4
]}

Vaske, Olena Morozova ^{[6
]}

Rodriguez, Analiz ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Coll Med, Dept Neurosurg, Little Rock, AR 72205 USA

[2] Med Univ South Carolina, Dept Neurosurg, Charleston, SC USA

[3] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR USA

[4] Univ Arkansas Med Sci, Dept Biomed Informat, Little Rock, AR USA

[5] Univ Arkansas Med Sci, Dept Biochem & Mol Biol, Little Rock, AR 72205 USA

[6] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA USA

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

基金：

美国国家卫生研究院;

关键词：

brain tumors; third generation sequencing; long-read sequencing; molecular diagnostics; liquid biopsy; CENTRAL-NERVOUS-SYSTEM; METHYLATION-BASED CLASSIFICATION; SINGLE-CELL; DNA METHYLATION; LIQUID BIOPSY; MOLECULAR CLASSIFICATION; EPIGENETIC DRIVERS; CHROMATIN STATES; PROGNOSTIC VALUE; RNA METHYLATION;

D O I：

10.3389/fonc.2024.1395985

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain tumors and genomics have a long-standing history given that glioblastoma was the first cancer studied by the cancer genome atlas. The numerous and continuous advances through the decades in sequencing technologies have aided in the advanced molecular characterization of brain tumors for diagnosis, prognosis, and treatment. Since the implementation of molecular biomarkers by the WHO CNS in 2016, the genomics of brain tumors has been integrated into diagnostic criteria. Long-read sequencing, also known as third generation sequencing, is an emerging technique that allows for the sequencing of longer DNA segments leading to improved detection of structural variants and epigenetics. These capabilities are opening a way for better characterization of brain tumors. Here, we present a comprehensive summary of the state of the art of third-generation sequencing in the application for brain tumor diagnosis, prognosis, and treatment. We discuss the advantages and potential new implementations of long-read sequencing into clinical paradigms for neuro-oncology patients.

引用

页数：16

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