Lipophilic fluorescent products as a potential biomarker of oxidative stress: A link between central (brain) and peripheral (blood)

被引:0
作者
Tarbali, Sepideh [1 ]
Dadkhah, Masoomeh [1 ]
Saadati, Hakimeh [1 ,2 ]
机构
[1] Ardabil Univ Med Sci, Pharmaceut Sci Res Ctr, Ardebil, Iran
[2] Ardabil Univ Med Sci, Fac Med, Dept Physiol, Ardebil, Iran
来源
JOURNAL OF RESEARCH IN MEDICAL SCIENCES | 2024年 / 29卷 / 01期
关键词
Brain; fluorescence; lipid peroxidation; malondialdehyde; oxidative stress; LIPOFUSCIN-LIKE PIGMENTS; LIPID-PEROXIDATION PRODUCTS; BODY-GAMMA-IRRADIATION; FREE-RADICAL DAMAGE; END-PRODUCTS; ALZHEIMERS-DISEASE; AMBIENT OXYGEN; TIME-COURSE; RAT-HEART; ACCUMULATION;
D O I
10.4103/jrms.jrms_671_23
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Oxidative stress plays a key role in brain damage because of the sensitivity of brain tissue to oxidative damage. Biomarkers with easy measurement can be a candidate for reflecting the oxidative stress issue in humans. For this reason, we need to focus on specific metabolic products of the brain. End products of free radical reactions such as malondialdehydes form fluorescent products known as lipophilic fluorescent products (LFPs). The distinctive feature of LFPs is their autofluorescent properties. LFPs are detectable in the brain and cerebrospinal fluid. Furthermore, because of the diffusion into the bloodstream, these lipophilic molecules can be detected in the blood. Accumulations of these compounds produce more reactive oxygen species and increase the sensitivity of cells to oxidative damage. Hence, LFPs can be considered a danger signal for neurons and can be introduced as a strong index of oxidative damage both in the central and in the peripheral.
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页数:8
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