New Meroterpenoids and α-Pyrone Derivatives Isolated from the Mangrove Endophytic Fungal Strain Aspergillus sp. GXNU-Y85

被引：0

作者：

Wang, Chungu ^{[1
]}

Wang, Fanfan ^{[2
]}

Tao, Pingfang ^{[2
]}

Shao, Yuanling ^{[1
]}

Li, Qing ^{[1
]}

Gu, Minmin ^{[1
]}

Liao, Zhixin ^{[1
]}

Qin, Feng ^{[2
]}

机构：

[1] Southeast Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Nanjing 211189, Peoples R China

[2] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin 537000, Peoples R China

来源：

MARINE DRUGS | 2024年 / 22卷 / 06期

关键词：

Aspergillus sp; meroterpenoids; alpha-pyrone derivatives; anti-proliferation activity; METABOLITES;

D O I：

10.3390/md22060277

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new meroterpenoids, aspergienynes O and P (1 and 2), one new natural compound, aspergienyne Q (3), and a new alpha-pyrone derivative named 3-(4-methoxy-2-oxo-2H-pyran-6-yl)butanoic acid (4) were isolated from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85, along with five known compounds (5-9). The absolute configurations of those new isolates were confirmed through extensive analysis using spectroscopic data (HRESIMS, NMR, and ECD). The pharmacological study of the anti-proliferation activity indicated that isolates 5 and 9 displayed moderate inhibitory effects against HeLa and A549 cells, with the IC50 values ranging from 16.6 to 45.4 mu M.

引用

页数：9

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