New Meroterpenoids and α-Pyrone Derivatives Isolated from the Mangrove Endophytic Fungal Strain Aspergillus sp. GXNU-Y85

被引：0
作者：
Wang, Chungu [1 ]
Wang, Fanfan [2 ]
Tao, Pingfang [2 ]
Shao, Yuanling [1 ]
Li, Qing [1 ]
Gu, Minmin [1 ]
Liao, Zhixin [1 ]
Qin, Feng [2 ]
机构：
[1] Southeast Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Nanjing 211189, Peoples R China
[2] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin 537000, Peoples R China
来源：
MARINE DRUGS | 2024年 / 22卷 / 06期
关键词：
Aspergillus sp; meroterpenoids; alpha-pyrone derivatives; anti-proliferation activity; METABOLITES;
D O I：
10.3390/md22060277
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new meroterpenoids, aspergienynes O and P (1 and 2), one new natural compound, aspergienyne Q (3), and a new alpha-pyrone derivative named 3-(4-methoxy-2-oxo-2H-pyran-6-yl)butanoic acid (4) were isolated from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85, along with five known compounds (5-9). The absolute configurations of those new isolates were confirmed through extensive analysis using spectroscopic data (HRESIMS, NMR, and ECD). The pharmacological study of the anti-proliferation activity indicated that isolates 5 and 9 displayed moderate inhibitory effects against HeLa and A549 cells, with the IC50 values ranging from 16.6 to 45.4 mu M.
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页数：9
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