Bovine hydroxyapatite for bone tissue engineering: Preparation, characterization, challenges, and future perspectives

被引:16
作者
Adhikara, Arrival Gusti [1 ]
Maharani, Agnesia Putri [2 ]
Puspitasari, Anggie [2 ]
Nuswantoro, Nuzul Ficky [3 ,5 ,6 ]
Juliadmi, Dian [3 ,5 ,6 ]
Maras, Muhammad Artha Jabatsudewa [2 ]
Nugroho, Doni Bowo [2 ]
Saksono, Budi [3 ,5 ,6 ]
Gunawarman [4 ]
机构
[1] Brawijaya Univ, Fac Agr Technol, Bioproc Engn, Malang 65145, East Java, Indonesia
[2] Sumateran Inst Technol, Fac Engn, Biomed Engn, South Lampung 35365, Lampung, Indonesia
[3] Natl Res & Innovat Agcy, Res Ctr Biomass & Bioprod, Bogor 16911, West Java, Indonesia
[4] Univ Andalas, Engn Fac, Dept Mech Engn, Padang, Indonesia
[5] Univ Gadjah Mada, Res Collaborat Ctr Biomed Scaffold, Yogyakarta, Indonesia
[6] Natl Res & Innovat Agcy, Yogyakarta, Indonesia
关键词
Bovine; Hydroxyapatite; Fracture; Bone graft; Tissue engineering; SINTERING TEMPERATURE; MECHANICAL-PROPERTIES; THIN-FILMS; SCAFFOLDS; PRECIPITATION; BIOMATERIALS; CALCINATION; NANOCRYSTALS; PERFORMANCE; FABRICATION;
D O I
10.1016/j.eurpolymj.2024.113171
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The demand for bone implant had been raising along with incidence of damaged bone by disease, trauma or accident. Using bone implant remains some clinical problems relating to infection and complication rate, nerve and vascular lesions, and postoperative pain. Bone tissue engineering is one of the most promising treatment for bone defect. Bovine hydroxyapatite (HAp) has been investigated for its potential use in bone tissue engineering due to its biocompatibility and similarity to natural bone. This review summaries various methods of bovine hydroxyapatite extraction and focusses on the characterizations which includes morphologies, phase crystallinities, and functional groups analysis. Instead of using synthesis hydroxyapatite, HAp from bovine appear to be promising regarding its inorganic residual composition for biocompatibility and bioactivity characteristics. Further research is needed to optimize its properties and improve its effectiveness in biomedical application. Research on the development of bovine hydroxyapatite should be contribute to overcoming the problem of the availability of quality graft materials and support the advancement of biomedicine.
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页数:12
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