Natural killer cell memory: challenges and opportunities for cancer immunotherapy

被引：3

作者：

Qu, Yuhua ^{[1
,2
]}

Zeng, Anhui ^{[1
,2
]}

Cheng, Yulu ^{[2
,3
]}

Li, Shengchun ^{[1
,2
]}

机构：

[1] Hosp Chengdu Univ Tradit Chinese Med, Dept Anorectal Surg, Chengdu 610072, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Chengdu 610072, Peoples R China

[3] Hosp Chengdu Univ Tradit Chinese Med, Dept Disinfect Supply Ctr, Chengdu, Peoples R China

来源：

CANCER BIOLOGY & THERAPY | 2024年 / 25卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Natural killer cell; natural killer cell memory; cytokine-induced memory NK cells; immunotherapy; HUMAN NK CELLS; ADOPTIVE TRANSFER; CYTOMEGALOVIRUS; DIFFERENTIATION; TRANSPLANTATION; INFECTION; RESPONSES;

D O I：

10.1080/15384047.2024.2376410

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Substantial advancements have been made in recent years in comprehending immune memory, which enhances the secondary response through prior infections. The ability of vertebrate T and B lymphocytes to exhibit classic recall responses has long been regarded as a distinguishing characteristic. However, natural killer (NK) cells have been found to acquire immunological memory in a manner akin to T and B cells. The fundamental principles derived from the investigation of NK cell memory offer novel insights into innate immunity and have the potential to pave the way for innovative strategies to enhance therapeutic interventions against multiple diseases including cancer. Here, we reviewed the fundamental characteristics, memory development and regulatory mechanism of NK cell memory. Moreover, we will conduct a comprehensive evaluation of the accomplishments, obstacles, and future direction pertaining to the utilization of NK cell memory in the field of cancer immunotherapy.

引用

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