Neuropsychiatric symptom burden in early-onset and late-onset Alzheimer's disease as a function of age

被引:1
作者
Polsinelli, Angelina J. [1 ,2 ]
Johnson, Sierah [3 ]
Crouch, Adele [4 ]
Lane, Kathleen A. [5 ]
Pena-Garcia, Alex [6 ]
Hammers, Dustin B. [1 ,2 ]
Wang, Sophia [2 ,7 ]
Gao, Sujuan [5 ]
Apostolova, Liana G. [1 ,2 ]
机构
[1] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
[2] Indiana Alzheimers Dis Res Ctr, Indianapolis, IN USA
[3] Univ Indianapolis, Dept Psychol Sci, Indianapolis, IN USA
[4] Indiana Univ, Sch Nursing, Sci Nursing Care Dept, Indianapolis, IN USA
[5] Indiana Univ Sch Med, Dept Biostat & Hlth Data Sci, Indianapolis, IN 46202 USA
[6] Marian Univ, Coll Osteopath Med, Indianapolis, IN USA
[7] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA
关键词
behavioral and psychological symptoms in dementia; early-onset Alzheimer's disease; late-onset Alzheimer's disease; neuropsychiatric symptoms; CLINICAL-DIAGNOSIS; CENTERS; ANXIETY; VERSION; YOUNG;
D O I
10.1002/alz.14042
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
INTRODUCTION We examined the burden of neuropsychiatric symptoms (NPSs) in early-onset (EO) and late-onset (LO) Alzheimer's disease (AD) and adjusted for age effects via the inclusion of cognitively unimpaired (CU) individuals. METHODS Cross-sectional data from 2940 EOAD, 8665 LOAD, and 8775 age-stratified CU individuals (early-CU, n = 2433; late-CU, n = 6342) from the National Alzheimer's Coordinating Center database were included. Fisher's exact tests compared EOAD and LOAD on the presence and severity of NPSs. Multiple logistic regression models included an age*diagnosis interaction to examine age effects. RESULTS Presence (ps < 0.0001) and severity (ps < 0.05) of NPS were greater in EOAD than in LOAD. However, after adjusting for base rates in NPS in CU individuals (age effects), only elation and eating behaviors were more frequent in EOAD (ps < 0.05) and nighttime behaviors more frequent and severe in LOAD (ps < 0.05). DISCUSSION Few NPSs were specific to the EOAD versus LOAD. Previous findings of greater NPS burden in EOAD may partially reflect age effects.
引用
收藏
页码:5481 / 5491
页数:11
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