Association of Fructosamine Levels With Glycemic Management in Children With Type 1 Diabetes as Determined by Continuous Glucose Monitoring: Results From the CGM TIME Trial

被引：0

作者：

Verbeeten, Kate C. ^{[1
]}

Tang, Ken ^{[2
]}

Courtney, Jennilea M. ^{[1
]}

Bradley, Brenda J. ^{[1
]}

Mcassey, Karen ^{[3
]}

Clarson, Cheril ^{[4
,5
]}

Kirsch, Susan ^{[6
]}

Curtis, Jacqueline R. ^{[7
]}

Mahmud, Farid H. ^{[7
]}

Richardson, Christine ^{[8
]}

Cooper, Tammy ^{[8
]}

Lawson, Margaret L. ^{[1
,8
]}

机构：

[1] CHEO Res Inst, Ottawa, ON, Canada

[2] Independent Stat Consultant, Richmond, BC, Canada

[3] McMaster Childrens Hosp, Hamilton, ON, Canada

[4] Childrens Hosp London, Hlth Sci Ctr, London, ON, Canada

[5] Lawson Hlth Res Inst, London, ON, Canada

[6] Markham Stouffville Hosp, Markham, ON, Canada

[7] Hosp Sick Children, Toronto, ON, Canada

[8] Childrens Hosp Eastern Ontario, Div Endocrinol, Ottawa, ON, Canada

来源：

CANADIAN JOURNAL OF DIABETES | 2024年 / 48卷 / 05期

关键词：

continuous glucose monitoring; fructosamine; glycemic management; pediatrics; type; 1; diabetes; GLYCATED ALBUMIN; HEMOGLOBIN; SYSTEM;

D O I：

10.1016/j.jcjd.2024.04.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Our aim in this study was to determine the correlation between serum fructosamine and average blood glucose, as measured by continuous glucose monitoring (CGM) in children with type 1 diabetes. Methods: Ninety-seven blood samples were collected from 70 participants in the Timing of Initiation of continuous glucose Monitoring in Established pediatric diabetes (CGM TIME) Trial. Each eligible participant had 3 weeks of CGM data with at least 60% CGM adherence before blood collection. Ordinary least-squares linear regression incorporating restricted cubic splines was used to determine the association between fructosamine levels and mean blood glucose. Results: An association was found between fructosamine and mean blood glucose, with an F statistic of 9.543 (p<0.001). Data were used to create a formula and conversion chart for calculating mean blood glucose from fructosamine levels for clinical use. Conclusions: There is a complex relationship between average blood glucose, as determined by CGM and fructosamine. Fructosamine levels may be clinically useful for assessing short-term glycemic management when CGM is not available. (c) 2024 Canadian Diabetes Association.

引用

页码：330 / 336.e2

页数：9

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