Synthesis and biological evaluation of aryl sulfonyl linked isoxazol-(pyridin-4-yl)pyrazolo [1,5-a]pyrimidines as cytotoxicity agents

被引:7
作者
Sabita, G. [1 ]
Savitha, R. [1 ]
Divya, K. [1 ]
Bhaskar, K. [1 ]
机构
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Telangana, India
来源
CHEMICAL DATA COLLECTIONS | 2022年 / 38卷
关键词
Dinaciclib; Pyrazolo [1,5-a]pyrimidine; Luminespib; 2-isoxazole and cytotoxicity activity; DERIVATIVES; DESIGN; INHIBITOR; PYRAZOLE; PURINES; KINASES; GROWTH;
D O I
10.1016/j.cdc.2021.100822
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new bunch of aryl sulfonyl linked isoxazol-(pyridin-4-yl)pyrazolo [1,5-a]pyrimidine compounds (11a-j) have been designed, developed and their structure were characterized by analytical techniques. Further, compounds were tested for their cytotoxicity activities towards human cancer cell lines like SiHa (Cervix cancer), A549 (Lung cancer), MCF-7 (Breast cancer) and Colo-205 (Colon cancer) using MTT assay and compared with standard drug, etoposide. Among all, compounds 11a, 11b, 11c, 11d and 11e demonstrated good cytotoxicity effects as standard drug. Specifically, two compounds (11a and 11e) displayed more potent activity.
引用
收藏
页数:7
相关论文
共 21 条
  • [1] Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides
    Abdou, IM
    Saleh, AM
    Zohdi, HF
    [J]. MOLECULES, 2004, 9 (03): : 109 - 116
  • [2] Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs
    Al-Tel, Taleb H.
    Al-Qawasmeh, Raed A.
    Zaarour, Rania
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (05) : 1874 - 1881
  • [3] Hit Identification and Biological Evaluation of Anticancer Pyrazolopyrimidines Endowed with Anti-inflammatory Activity
    Alcaro, Stefano
    Artese, Anna
    Botta, Maurizio
    Zizzari, Alessandra T.
    Orallo, Francisco
    Ortuso, Francesco
    Schenone, Silvia
    Brullo, Chiara
    Yanez, Matilde
    [J]. CHEMMEDCHEM, 2010, 5 (08) : 1242 - 1246
  • [4] EFFECTS OF 4-HYDROXYPYRAZOLO(3,4-D)PYRIMIDINE UPON CATABOLISM OF PURINES BY VARIOUS TISSUES OF RAT AND UPON RATE OF GROWTH OF MORRIS 5123-C HEPATOMA
    ALEXANDE.JA
    WHEELER, GP
    HILL, DD
    MORRIS, HP
    [J]. BIOCHEMICAL PHARMACOLOGY, 1966, 15 (07) : 881 - &
  • [5] Synthesis and nicotinic activity of epiboxidine: An isoxazole analogue of epibatidine
    Badio, B
    Garraffo, HM
    Plummer, CV
    Padgett, WL
    Daly, JW
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 321 (02) : 189 - 194
  • [6] THE SYNTHESIS AND PROPERTIES OF 6-CHLOROPURINE AND PURINE
    BENDICH, A
    RUSSELL, PJ
    FOX, JJ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (23) : 6073 - 6077
  • [7] Daidone G, 1999, ARCH PHARM, V332, P50, DOI 10.1002/(SICI)1521-4184(19993)332:2<50::AID-ARDP50>3.0.CO
  • [8] 2-S
  • [9] SYNTHESIS AND STUDY OF THE POTENTIAL ANTI-ALLERGIC ACTIVITY OF SOME PYRAZOLE DERIVATIVES
    DIPARSIA, MT
    SUAREZ, C
    VITOLO, MJ
    MARQUEZ, VE
    BEYER, B
    URBINA, C
    HURTADO, I
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (01) : 117 - 119
  • [10] Effects of the 2-amino-3-hydroxy-5-methyl-4-isoxazole-proprionic acid/kainate antagonist LY293558 on spontaneous and evoked postoperative pain
    Gilron, I
    Max, MB
    Lee, G
    Booher, SL
    Sang, CN
    Chappell, AS
    Dionne, RA
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2000, 68 (03) : 320 - 327