Impact of Lipoprotein(a) Level on Low-Density Lipoprotein Cholesterol- or Apolipoprotein B-Related Risk of Coronary Heart Disease

被引：13

作者：

Arnold, Natalie ^{[1
,2
,3
]}

Blaum, Christopher ^{[1
,3
]}

Gossling, Alina ^{[1
,3
]}

Brunner, Fabian J. ^{[1
,2
,3
]}

Bay, Benjamin ^{[1
,2
,3
]}

Zeller, Tanja ^{[1
,2
,3
,4
]}

Ferrario, Marco M. ^{[5
]}

Brambilla, Paolo ^{[6
]}

Cesana, Giancarlo ^{[6
]}

Leoni, Valerio ^{[7
]}

Palmieri, Luigi ^{[8
]}

Donfrancesco, Chiara ^{[8
]}

Ojeda, Francisco ^{[1
,3
]}

Linneberg, Allan ^{[9
,10
]}

Soederberg, Stefan ^{[11
]}

Iacoviello, Licia ^{[12
,13
]}

Gianfagna, Francesco ^{[5
,14
]}

Costanzo, Simona ^{[13
]}

Sans, Susana ^{[15
]}

Veronesi, Giovanni ^{[5
]}

Thorand, Barbara ^{[16
,17
]}

Peters, Annette ^{[16
,17
,18
]}

Tunstall-Pedoe, Hugh ^{[19
]}

Kee, Frank ^{[20
]}

Salomaa, Veikko ^{[21
]}

Schnabel, Renate B. ^{[1
,2
,3
]}

Kuulasmaa, Kari ^{[21
]}

Blankenberg, Stefan ^{[1
,2
,3
]}

Waldeyer, Christoph ^{[1
,2
,3
]}

Koenig, Wolfgang ^{[22
,23
,24
]}

机构：

[1] Univ Heart & Vasc Ctr Hamburg, Univ Med Ctr Hamburg Eppendorf, Dept Cardiol, Hamburg, Germany

[2] German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Kiel Luebeck, Hamburg, Germany

[3] Univ Heart & Vasc Ctr Hamburg, Univ Med Ctr Hamburg Eppendorf, Ctr Populat Hlth Innovat POINT, Hamburg, Germany

[4] Univ Heart & Vasc Ctr Hamburg, Univ Ctr Cardiovasc Sci, Hamburg, Germany

[5] Univ Insubria, Res Ctr Epidemiol & Prevent Med EPIMED, Dept Med & Surg, Varese, Italy

[6] Univ Milano Bicocca, Dept Med & Surg, Milan, Italy

[7] Univ Milano Bicocca, Hosp Pioof Desio 11, Sch Med & Surg, Lab Clin Pathol, Milan, Italy

[8] Ist Super Sanita ISS, Dept Cardiovasc Endocrine Metab Dis & Aging, Rome, Italy

[9] Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark

[10] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[11] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[12] LUM Univ, Dept Med & Surg, Casamassima, Italy

[13] IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy

[14] Mediterranea Cardioctr, Naples, Italy

[15] Catalan Dept Hlth, Barcelona, Spain

[16] German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany

[17] Ludwig Maximilians Univ Munchen, Inst Med Informat Proc Biometry & Epidemiol IBE, Munich, Germany

[18] German Ctr Cardiovasc Dis Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany

[19] Univ Dundee, Inst Cardiovasc Res, Cardiovasc Epidemiol Unit, Dundee, Scotland

[20] Queens Univ Belfast, Ctr Publ Hlth, Belfast, North Ireland

[21] Finnish Inst Hlth & Welf THL, Dept Publ Hlth & Welf, Helsinki, Finland

[22] German Heart Ctr, Lazarettstr 36, D-80636 Munich, Germany

[23] Tech Univ Munich, Lazarettstr 36, D-80636 Munich, Germany

[24] Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2024年 / 84卷 / 02期

关键词：

apolipoprotein B; coronary heart disease; general population; lipoprotein(a); low-density lipoprotein; OXIDIZED PHOSPHOLIPIDS; LDL-C; PLASMA;

D O I：

10.1016/j.jacc.2024.04.050

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Conventional low-density lipoprotein cholesterol (LDL-C) quantification includes cholesterol attributable to lipoprotein(a) (Lp(a)-C) due to their overlapping densities. Objectives The purposes of this study were to compare the association between LDL-C and LDL-C corrected for Lp(a)-C (LDLLp(a)corr) with incident coronary heart disease (CHD) in the general population and to investigate whether concomitant Lp(a) values influence the association of LDL-C or apolipoprotein B (apoB) with coronary events. Methods Among 68,748 CHD-free subjects at baseline LDLLp(a)corr was calculated as "LDL-C-Lp(a)-C," where Lp(a)-C was 30% or 17.3% of total Lp(a) mass. Fine and Gray competing risk-adjusted models were applied for the association between the outcome incident CHD and: 1) LDL-C and LDLLp(a)corr in the total sample; and 2) LDL-C and apoB after stratification by Lp(a) mass (>=/<90th percentile). Results Similar risk estimates for incident CHD were found for LDL-C and LDL-C-Lp(a)corr30 or LDL-C-Lp(a)corr17.3 (subdistribution HR with 95% CI) were 2.73 (95% CI: 2.34-3.20) vs 2.51 (95% CI: 2.15-2.93) vs 2.64 (95% CI: 2.26-3.10), respectively (top vs bottom fifth; fully adjusted models). Categorization by Lp(a) mass resulted in higher subdistribution HRs for uncorrected LDL-C and incident CHD at Lp(a) >= 90th percentile (4.38 [95% CI: 2.08-9.22]) vs 2.60 [95% CI: 2.21-3.07]) at Lp(a) <90th percentile (top vs bottom fifth; P(interaction)0.39). In contrast, apoB risk estimates were lower in subjects with higher Lp(a) mass (2.43 [95% CI: 1.34-4.40]) than in Lp(a) <90th percentile (3.34 [95% CI: 2.78-4.01]) (P(interaction)0.49). Conclusions Correction of LDL-C for its Lp(a)-C content provided no meaningful information on CHD-risk estimation at the population level. Simple categorization of Lp(a) mass (>=/<90th percentile) influenced the association between LDL-C or apoB with future CHD mostly at higher Lp(a) levels.

引用

页码：165 / 177

页数：13

共 31 条

[1] Improving prediction of ischemic cardiovascular disease in the general population using apolipoprotein B -: The Copenhagen city heart study [J].

Benn, Marianne ;

Nordestgaard, Borge G. ;

Jensen, Gorm Boje ;

Tybjærg-Hansen, Anne .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (03) :661-670

[2] A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma [J].

Bergmark, Claes ;

Dewan, Asheesh ;

Orsoni, Alexina ;

Merki, Esther ;

Miller, Elizabeth R. ;

Shin, Min-Jeong ;

Binder, Christoph J. ;

Horkko, Sohvi ;

Krauss, Ronald M. ;

Chapman, M. John ;

Witztum, Joseph L. ;

Tsimikas, Sotirios .

JOURNAL OF LIPID RESEARCH, 2008, 49 (10) :2230-2239

[3] Lipoprotein(a) Testing Trends in a Large Academic Health System in the United States [J].

Bhatia, Harpreet S. ;

Hurst, Samantha ;

Desai, Paresh ;

Zhu, Wenhong ;

Yeang, Calvin .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2023, 12 (18)

[4] Lipoprotein(a) Is Markedly More Atherogenic Than LDL An Apolipoprotein B-Based Genetic Analysis [J].

Bjornson, Elias ;

Adiels, Martin ;

Taskinen, Marja-Riitta ;

Burgess, Stephen ;

Chapman, M. John ;

Packard, Chris J. ;

Boren, Jan .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2024, 83 (03) :385-395

[5] Discordance between lipoprotein particle number and cholesterol content: an update [J].

Cantey, Eric P. ;

Wilkins, John T. .

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2018, 25 (02) :130-136

[6] Lp(a): When and how to measure it [J].

Cegla, Jaimini ;

France, Michael ;

Marcovina, Santica M. ;

Neely, R. Dermot G. .

ANNALS OF CLINICAL BIOCHEMISTRY, 2021, 58 (01) :16-21

[7] Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation [J].

Fatica, Erica M. ;

Meeusen, Jeffrey W. ;

Vasile, Vlad C. ;

Jaffe, Allan S. ;

Donato, Leslie J. .

CLINICAL BIOCHEMISTRY, 2020, 86 :45-51

[8] Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk [J].

Ference, Brian A. ;

Kastelein, John J. P. ;

Ginsberg, Henry N. ;

Chapman, John ;

Nicholls, Stephen J. ;

Ray, Kausik K. ;

Packard, Chris J. ;

Laufs, Ulrich ;

Brook, Robert D. ;

Oliver-Williams, Clare ;

Butterworth, Adam S. ;

Danesh, John ;

Smith, George Davey ;

Catapano, Alberico L. ;

Sabatine, Marc S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 318 (10) :947-956

[9]

GAUBATZ JW, 1983, J BIOL CHEM, V258, P4582

[10] Physiological Bases for the Superiority of Apolipoprotein B Over Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk [J].

Glavinovic, Tamara ;

Thanassoulis, George ;

de Graaf, Jacqueline ;

Couture, Patrick ;

Hegele, Robert A. ;

Sniderman, Allan D. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2022, 11 (20)

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