Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis

被引：1

作者：

Kioko, Mwikali ^{[1
]}

Mwangi, Shaban ^{[1
]}

Njunge, James M. ^{[1
]}

Berkley, James A. ^{[1
,2
]}

Bejon, Philip ^{[1
,2
]}

Abdi, Abdirahman I. ^{[1
,2
,3
]}

机构：

[1] KEMRI Wellcome Trust Res Programme, Biosci Dept, Kilifi, Kenya

[2] Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England

[3] Pwani Univ, Pwani Univ Biosci Res Ctr, Kilifi, Kenya

来源：

MOLECULAR NEUROBIOLOGY | 2025年 / 62卷 / 02期

基金：

英国惠康基金;

关键词：

Cerebral malaria; Alzheimer's disease; Plasmodium falciparum; Amyloidosis; Apolipoprotein E; Amyloid-beta; APOLIPOPROTEIN-E; A-BETA; MOUSE MODEL; ACCUMULATION; DEPOSITION; RISK; MICE;

D O I：

10.1007/s12035-024-04366-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although most children with cerebral malaria fully recover, more than a fifth of the survivors develop post-discharge neurodevelopmental sequelae suggestive of advanced neuronal injury. However, the cerebral molecular processes initiating neurological dysfunction in cerebral malaria are still debatable. In this article, we explore available data and hypothesise that cerebral malaria might be linked to APOE-mediated amyloidosis, one of the pathological processes associated with Alzheimer's disease. If our hypothesis is tested and found to be true, it could have far-reaching implications for what we know about cerebral malaria pathogenesis.

引用

页码：1720 / 1725

页数：6

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