The role of the cGAS-STING pathway in metabolic diseases

被引：7
作者：
Xu, Qian [1 ]
Xing, Jie [2 ]
Wang, Shengjun [2 ]
Peng, Huiyong [2 ]
Liu, Yingzhao [1 ]
机构：
[1] Nanjing Med Univ, Jiangsu Univ, Affiliated Peoples Hosp, Zhenjiang Med Sch,Dept Endocrinol, Zhenjiang 212002, Peoples R China
[2] Nanjing Med Univ, Jiangsu Univ, Affiliated Peoples Hosp, Zhenjiang Med Sch,Dept Lab Med, Zhenjiang 212002, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 12期
关键词：
cGAS; STING; Metabolic dysregulation; Chronic inflammation; Mitochondria; Treatment; CYCLIC GMP-AMP; SMALL-MOLECULE INHIBITION; DNA SENSOR; ACTIVATION; INFLAMMATION; REVEALS; 2ND-MESSENGER; MACROPHAGES; PROGRESSION; MECHANISMS;
D O I：
10.1016/j.heliyon.2024.e33093
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a critical innate immune pathway primarily due to its vital DNA sensing mechanism in pathogen defence. Recent research advances have shown that excessive activation or damage to the cGAS-STING pathway can exacerbate chronic inflammatory responses, playing a significant role in metabolic dysfunction and aging, leading to the development of related diseases such as obesity, osteoporosis, and neurodegenerative diseases. This article reviews the structure and biological functions of the cGAS-STING signaling pathway and discusses in detail how this pathway regulates the occurrence and development of metabolic and age-related diseases. Additionally, this article introduces potential small molecule drugs targeting cGAS and STING, aiming to provide new research perspectives for studying the pathogenesis and treatment of metabolic-related diseases.
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页数：10
相关论文
共 94 条
[1]   Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING [J].
Aarreberg, Lauren D. ;
Esser-Nobis, Katharina ;
Driscoll, Connor ;
Shuvarikov, Andrey ;
Roby, Justin A. ;
Gale, Michael, Jr. .
MOLECULAR CELL, 2019, 74 (04) :801-+
[2]   Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP [J].
Ablasser, Andrea ;
Schmid-Burgk, Jonathan L. ;
Hemmerling, Inga ;
Horvath, Gabor L. ;
Schmidt, Tobias ;
Latz, Eicke ;
Hornung, Veit .
NATURE, 2013, 503 (7477) :530-+
[3]   cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING [J].
Ablasser, Andrea ;
Goldeck, Marion ;
Cavlar, Taner ;
Deimling, Tobias ;
Witte, Gregor ;
Roehl, Ingo ;
Hopfner, Karl-Peter ;
Ludwig, Janos ;
Hornung, Veit .
NATURE, 2013, 498 (7454) :380-+
[4]   Antimalarial Drugs as Immune Modulators: New Mechanisms for Old Drugs [J].
An, Jie ;
Minie, Mark ;
Sasaki, Tomikazu ;
Woodward, Joshua J. ;
Elkon, Keith B. .
ANNUAL REVIEW OF MEDICINE, VOL 68, 2017, 68 :317-330
[5]   cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders [J].
Andreeva, Liudmila ;
Hiller, Bjoern ;
Kostrewa, Dirk ;
Laessig, Charlotte ;
Mann, Carina C. de Oliveira ;
Drexler, David Jan ;
Maiser, Andreas ;
Gaidt, Moritz ;
Leonhardt, Heinrich ;
Hornung, Veit ;
Hopfner, Karl-Peter .
NATURE, 2017, 549 (7672) :394-+
[6]   Mitochondria as a Cellular Hub in Infection and Inflammation [J].
Andrieux, Pauline ;
Chevillard, Christophe ;
Cunha-Neto, Edecio ;
Nunes, Joao Paulo Silva .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (21)
[7]   DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway [J].
Bai, Juli ;
Cervantes, Christopher ;
Liu, Juan ;
He, Sijia ;
Zhou, Haiyan ;
Zhang, Bilin ;
Cai, Huan ;
Yin, Dongqing ;
Hu, Derong ;
Li, Zhi ;
Chen, Hongzhi ;
Gao, Xiaoli ;
Wang, Fang ;
O'Connor, Jason C. ;
Xu, Yong ;
Liu, Meilian ;
Dong, Lily Q. ;
Liu, Feng .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (46) :12196-12201
[8]   Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA [J].
Barnett, Katherine C. ;
Coronas-Serna, Julia M. ;
Zhou, Wen ;
Ernandes, Michael J. ;
Cao, Anh ;
Kranzusch, Philip J. ;
Kagan, Jonathan C. .
CELL, 2019, 176 (06) :1432-+
[9]  
Cai DC, 2021, AGING-US, V13, P12160, DOI 10.18632/aging.202929
[10]   Mitophagy in Alzheimer's Disease and Other Age-Related Neurodegenerative Diseases [J].
Cai, Qian ;
Jeong, Yu Young .
CELLS, 2020, 9 (01)
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