Lewis acid-catalyzed phosphinoylation and halogenation of α,β-unsaturated ketones: access to γ-halo allylic phosphonates

被引：2

作者：

Wei, Xiao-Hong ^{[1
]}

Xue, Ya-Wen ^{[1
]}

Bai, Chun-Yuan ^{[1
]}

Liu, Xuan ^{[1
]}

Wang, Xiao-Hong ^{[1
]}

Wang, Yan-Bin ^{[1
]}

Su, Qiong ^{[1
]}

机构：

[1] Northwest Minzu Univ, Key Lab Util Environm Friendly Composite Mat & Bio, Gansu Prov Biomass Funct Composites Engn Res Ctr, Coll Chem Engn,Key Lab Environm Friendly Composite, 1 Northwest Xincun, Lanzhou 730030, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 16期

关键词：

FACILE SYNTHESIS; C BOND; PHOSPHORYLATION; ALDEHYDES; ALCOHOLS; OXIDES;

D O I：

10.1039/d4qo00748d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Lewis acid-catalyzed phosphinoylation and halogenation of alpha,beta-unsaturated ketones to synthesize gamma-halo allylic phosphonates is described. This transformation consists of a phospha-Michael addition, unimolecular elimination dehydration cascade reaction for the introduction of versatile groups (-P(O)R3R4 and -X) in the resulting gamma-substituted allylic phosphonates with high regio- and stereoselectivity. A Lewis acid-catalyzed phosphinoylation and halogenation of alpha,beta-unsaturated ketones to synthesize gamma-halo allylic phosphonates is described.

引用

页码：4385 / 4390

页数：6

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