Lewis acid-catalyzed phosphinoylation and halogenation of α,β-unsaturated ketones: access to γ-halo allylic phosphonates

被引：2
作者：
Wei, Xiao-Hong [1 ]
Xue, Ya-Wen [1 ]
Bai, Chun-Yuan [1 ]
Liu, Xuan [1 ]
Wang, Xiao-Hong [1 ]
Wang, Yan-Bin [1 ]
Su, Qiong [1 ]
机构：
[1] Northwest Minzu Univ, Key Lab Util Environm Friendly Composite Mat & Bio, Gansu Prov Biomass Funct Composites Engn Res Ctr, Coll Chem Engn,Key Lab Environm Friendly Composite, 1 Northwest Xincun, Lanzhou 730030, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 16期
关键词：
FACILE SYNTHESIS; C BOND; PHOSPHORYLATION; ALDEHYDES; ALCOHOLS; OXIDES;
D O I：
10.1039/d4qo00748d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Lewis acid-catalyzed phosphinoylation and halogenation of alpha,beta-unsaturated ketones to synthesize gamma-halo allylic phosphonates is described. This transformation consists of a phospha-Michael addition, unimolecular elimination dehydration cascade reaction for the introduction of versatile groups (-P(O)R3R4 and -X) in the resulting gamma-substituted allylic phosphonates with high regio- and stereoselectivity. A Lewis acid-catalyzed phosphinoylation and halogenation of alpha,beta-unsaturated ketones to synthesize gamma-halo allylic phosphonates is described.
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收藏
页码：4385 / 4390
页数：6
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