Factors Associated With Loss to Follow-Up in Surgical Trials: A Systematic Review and Meta-Analysis

被引：1

作者：

Walker, Richard J. B. ^{[1
,2
]}

Choi, Woo Jin ^{[1
,2
]}

Ribeiro, Tiago ^{[1
,2
]}

Habib, Razan A. ^{[1
]}

Zhu, Alice ^{[1
]}

Tan, Chunyi ^{[1
]}

Bui, Evan Chung ^{[1
]}

da Costa, Bruno R. ^{[2
,3
,4
]}

Karanicolas, Paul J. ^{[1
,2
,5
,6
]}

机构：

[1] Univ Toronto, Dept Surg, Div Gen Surg, Toronto, ON, Canada

[2] Univ Toronto, Inst Hlth Policy Management & Evaluat, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[3] St Michaels Hosp, Li Ka Shing Knowledge Inst, Appl Hlth Res Ctr, Toronto, ON, Canada

[4] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit & Epidemiol Studies Unit CTSU, Oxford, England

[5] Sunnybrook Hlth Sci Ctr, Div Gen Surg, Toronto, ON, Canada

[6] Sunnybrook Hlth Sci Ctr, 2075 Bayview Ave Room T2 16, Toronto, ON M4N 3M5, Canada

来源：

JOURNAL OF SURGICAL RESEARCH | 2024年 / 300卷

关键词：

Bias; Compliance; Lost to follow-up; Outcome and process assessment; Randomized controlled trial; Surgery; RANDOMIZED CONTROLLED-TRIALS; EXPLANATION;

D O I：

10.1016/j.jss.2024.04.054

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Introduction: Loss to follow-up (LTFU) distorts results of randomized controlled trials (RCTs). Understanding trial characteristics that contribute to LTFU may enable investigators to anticipate the extent of LTFU and plan retention strategies. The objective of this systematic review and meta-analysis was to investigate the extent of LTFU in surgical RCTs and evaluate associations between trial characteristics and LTFU. Methods: MEDLINE, Embase, and PubMed Central were searched for surgical RCTs published between January 2002 and December 2021 in the 30 highest impact factor surgical journals. Two-hundred eligible RCTs were randomly selected. The pooled LTFU rate was estimated using random intercept Poisson regression. Associations between trial characteristics and LTFU were assessed using metaregression. Results: The 200 RCTs included 37,914 participants and 1307 LTFU events. The pooled LTFU rate was 3.10 participants per 100 patient-years (95% confidence interval [CI] 1.85-5.17). Trial characteristics associated with reduced LTFU were standard-of-care outcome assessments (rate ratio [RR] 0.17; 95% CI 0.06-0.48), surgery for transplantation (RR 0.08; 95% CI 0.01-0.43), and surgery for cancer (RR 0.10; 95% CI 0.02-0.53). Increased LTFU was associated with patient-reported outcomes (RR 14.21; 95% CI 4.82-41.91) and follow-up duration >= three months (odds ratio 10.09; 95% CI 4.79-21.28).

引用

页码：33 / 42

页数：10