Safety and Tolerability of NIM-1324, an Oral, Once-daily LANCL2 Agonist, in a Randomized, Double-Blind, Placebo-Controlled Phase 1 Study in Normal Healthy Volunteers

被引:0
作者
Leber, Andrew [1 ]
Hontecillas, Raquel [1 ]
Juni, Nuria Tubau [1 ]
Bassaganya-Riera, Josep [1 ]
机构
[1] NIMML Inst, Blacksburg, VA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2337
引用
收藏
页码:4631 / 4632
页数:2
相关论文
共 50 条
[21]   Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial [J].
Pitchford, Lisa M. ;
Driver, Patricia M. ;
Fuller, John C., Jr. ;
Akers, Wendell S. ;
Abumrad, Naji N. ;
Amarnath, Venkataraman ;
Milne, Ginger L. ;
Chen, Sheau-Chiann ;
Ye, Fei ;
Roberts, L. Jackson, II ;
Shoemaker, M. Benjamin ;
Oates, John A. ;
Rathmacher, John A. ;
Boutaud, Olivier .
BMC PHARMACOLOGY & TOXICOLOGY, 2020, 21 (01)
[22]   Once-Daily Suvecaltamide Pharmacokinetics, Safety, & Tolerability-Phase 1, Randomized, Double-Blind, Multiple Ascending Dose Study [J].
Markova, S. ;
Baladi, M. ;
Lee, M. ;
Chen, C. .
MOVEMENT DISORDERS, 2024, 39 :S290-S291
[23]   A phase 1, randomized, double-blind, placebo-controlled trial investigating the pharmacokinetics, pharmacodynamics, safety and tolerability of oral semaglutide in healthy Chinese subjects [J].
Xie, Panpan ;
Abildlund, Morten T. ;
Baekdal, Tine A. ;
He, Xuemei ;
Lyauk, Yassine K. ;
Patted, Usha Rani H. ;
Ning, Zu ;
Shi, Aixin .
DIABETES OBESITY & METABOLISM, 2024, 26 (08) :3068-3077
[24]   Safety, tolerability, and pharmacokinetics of oral (S)-oxiracetam in Chinese healthy volunteers: A randomized, double-blind, controlled phase I study [J].
Zhang, Ting ;
Tao, Yi ;
Pu, Junliang ;
Zhu, Mingxue ;
Wan, Lei ;
Tang, Chengyong .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2024, 192
[25]   Multiple once-daily subcutaneous doses of pasireotide were well tolerated in healthy male volunteers: a randomized, double-blind, placebo-controlled, cross-over, Phase I study [J].
Christoph Beglinger ;
Ke Hu ;
Ying Wang ;
Emmanuel Bouillaud ;
Christelle Darstein ;
Yanfeng Wang ;
Pharis Mohideen .
Endocrine, 2012, 42 :366-374
[26]   Multiple once-daily subcutaneous doses of pasireotide were well tolerated in healthy male volunteers: a randomized, double-blind, placebo-controlled, cross-over, Phase I study [J].
Beglinger, Christoph ;
Hu, Ke ;
Wang, Ying ;
Bouillaud, Emmanuel ;
Darstein, Christelle ;
Wang, Yanfeng ;
Mohideen, Pharis .
ENDOCRINE, 2012, 42 (02) :366-374
[27]   Glimepiride, a new once-daily sulfonylurea - A double-blind placebo-controlled study of NIDDM patients [J].
Rosenstock, J ;
Samols, E ;
Muchmore, DB ;
Schneider, J ;
Abelove, WA ;
Asplin, CM ;
Bergstrom, RW ;
Berhanu, P ;
Borowski, GD ;
Browning, GV ;
Comstock, JP ;
Friedman, NM ;
Gollapudi, GM ;
Graber, AL ;
Guthrie, RA ;
Henson, BE ;
Hershon, KS ;
Krosnick, A ;
Levin, SR ;
Levy, P ;
Lock, JP ;
Lodewick, PA ;
Mersey, JH ;
Michie, DD ;
Mather, SR ;
Musey, VC ;
Palmer, JP ;
Peters, PJ ;
Poulos, JT ;
Prendergast, JJ ;
Reynolds, LR ;
Roberts, VL ;
Rosenblatt, S ;
Rosenthal, AR ;
Cavanaugh, JJ ;
Schneider, SH ;
Snyder, JW ;
Sweet, RA ;
Vestal, RE .
DIABETES CARE, 1996, 19 (11) :1194-1199
[28]   Safety, Tolerability, and Pharmacokinetics of FAAH Inhibitor BIA 10-2474: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Volunteers [J].
Rocha, Jose-Francisco ;
Santos, Ana ;
Gama, Helena ;
Moser, Paul ;
Falcao, Amilcar ;
Pressman, Peter ;
Wallace Hayes, A. ;
Soares-da-Silva, Patricio .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2022, 111 (02) :391-403
[29]   A Randomized, Placebo-Controlled, Double-Blind Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Repeated Doses of Mirogabalin in Healthy Asian Volunteers [J].
Jansen, Mendel ;
Warrington, Steven ;
Dishy, Victor ;
Ohwada, Shoichi ;
Johnson, Lisa ;
Brown, Karen ;
Ishizuka, Hitoshi .
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2018, 7 (06) :661-669
[30]   Metabolic efficacy and safety of once-daily pioglitazone monotherapy in patients with type 2 diabetes:: A double-blind, placebo-controlled study [J].
Scherbaum, WA ;
Göke, B .
HORMONE AND METABOLIC RESEARCH, 2002, 34 (10) :589-595