Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

被引：6

作者：

Xiang, Maya ^{[1
,2
,3
]}

Yang, Chunli ^{[1
,2
]}

Zhang, Li ^{[1
,2
,4
]}

Wang, Siyi ^{[1
,2
]}

Ren, Ya ^{[1
,2
]}

Gou, Maling ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu, Peoples R China

[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China

[3] Univ Washington Seattle Campus, Dept Chem, Seattle, WA USA

[4] Huahang Microcreate Technol Co Ltd, Chengdu, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2024年 / 12卷 / 24期

关键词：

CHITOSAN; VACCINATION; PATCH;

D O I：

10.1039/d4tb00659c

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Immunotherapy is an important approach in cancer treatment. Transdermal administration is emerging as a promising method for delivering immunotherapeutics. Dissolving microneedles are made mainly of soluble or biodegradable polymers and have garnered widespread attention due to their painlessness, safety, convenience, excellent drug loading capacity, and easy availability of various materials, making them an ideal transdermal delivery system. This review comprehensively summarized the preparation methods, materials, and applications of dissolving microneedles in cancer vaccines, immune checkpoint inhibitors, and adoptive cell therapy. Additionally, the challenges and perspectives associated with their future clinical translation are discussed. Dissolving microneedles mediated immunotherapeutics delivery for cancer treatment.

引用

页码：5812 / 5822

页数：11

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