Remarkable Improvement of Diabetic Nephropathy in Transplanted Allograft after Kidney Transplantation

被引：0

作者：

Tanaka, Ryo ^{[1
]}

Imamura, Ryoichi ^{[1
,2
]}

Matsumura, Soichi ^{[1
]}

Fukae, Shota ^{[1
]}

Taniguchi, Ayumu ^{[1
,3
]}

Nakazawa, Shigeaki ^{[1
]}

Yamanaka, Kazuaki ^{[1
]}

Namba-Hamano, Tomoko ^{[4
]}

Kakuta, Yoichi ^{[1
]}

Takao, Tetsuya ^{[5
]}

Fushimi, Hiroaki ^{[6
]}

Nonomura, Norio ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Urol, Osaka, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Urol, Nagasaki, Japan

[3] Juntendo Univ Urayasu Hosp, Dept Urol, Chiba, Japan

[4] Osaka Univ, Grad Sch Med, Dept Nephrol, Osaka, Japan

[5] Osaka Gen Med Ctr, Dept Urol, Osaka, Japan

[6] Osaka Gen Med Ctr, Dept Pathol, Osaka, Japan

来源：

NEPHRON | 2024年 / 148卷 / 07期

关键词：

Kidney transplantation; Donor-derived diabetic nephropathy; Transplanted kidney biopsy; REVERSAL; DONOR;

D O I：

10.1159/000535877

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Although glomerular damage caused by diabetic nephropathy was thought to be irreversible, in recent years, there have been reports on improvement in glomerular damage with strict glycemic control. However, few reports are available on the pathologic course after renal transplantation of donor-derived grafts with findings of diabetic nephropathy. A 53-year-old woman underwent an ABO blood-type compatible living-donor renal transplant. The recipient had no history of diabetes, and fasting blood glucose and hemoglobin A1c levels were both normal. The donor was a 57-year-old male who had received treatment for type 2 diabetes mellitus for 10 years. Transplant renal biopsy performed 1 h after revascularization showed mesangial matrix expansion and arterial hyalinosis due to diabetic nephropathy. The blood glucose level was within the normal range after transplantation. Mesangial matrix expansion and arterial hyalinosis disappeared in allograft biopsy samples 7 years after transplantation. We observed significant improvement in the pathological findings of donor-derived diabetic nephropathy after renal transplantation in the subsequent follow-ups.

引用

页码：468 / 473

页数：6

共 12 条

[1]

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[2]

ABOUNA GM, 1983, LANCET, V2, P1274

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