EZH2: The roles in targeted therapy and mechanisms of resistance in breast cancer

被引：11
作者：
Chen, Yun [1 ,2 ]
Zhu, Hongyan [1 ,2 ]
Luo, Yi [2 ,3 ]
Tong, Shuangmei [1 ,2 ]
Liu, Yan [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Clin Pharm, Sch Med, Shanghai 200092, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Clin Pharm Innovat Inst, Shanghai 200092, Peoples R China
[3] Biotheus Inc, Zhuhai 519080, Guangdong, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 175卷
基金：
中国国家自然科学基金;
关键词：
EZH2; Resistance; Breast cancer; Targeted therapy; HISTONE METHYLTRANSFERASE EZH2; REPRESSIVE COMPLEX 2; H3; LYSINE; 27; PI3K/AKT/MTOR PATHWAY; EPIGENETIC REGULATION; SELECTIVE INHIBITOR; ANTITUMOR IMMUNITY; GENE REPRESSION; DUAL INHIBITOR; CELL IDENTITY;
D O I：
10.1016/j.biopha.2024.116624
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Drug resistance presents a formidable challenge in the realm of breast cancer therapy. Accumulating evidence suggests that enhancer of zeste homolog 2 (EZH2), a component of the polycomb repressive complex 2 (PRC2), may serve as a key regulator in controlling drug resistance. EZH2 overexpression has been observed in breast cancer and many other malignancies, showing a strong correlation with poor outcomes. This review aims to summarize the mechanisms by which EZH2 regulates drug resistance, with a specific focus on breast cancer, in order to provide a comprehensive understanding of the underlying molecular processes. Additionally, we will discuss the current strategies and outcomes of targeting EZH2 using both single agents and combination therapies, with the goal of offering improved guidance for the clinical treatment of breast cancer patients who have developed drug resistance.
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页数：17
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