Case report: Atypical lipomatous tumor of the thigh in a four-year-old girl

被引:0
|
作者
Ogawa, Itaru [1 ]
Hakozaki, Michiyuki [1 ,2 ]
Kaneuchi, Yoichi [1 ]
Suzuki, Takeo [1 ]
Nikaido, Takuya [1 ]
Yamada, Shoki [3 ]
Utsumi, Akihito [3 ]
Hasegawa, Osamu [4 ]
Sano, Hideki [5 ]
Matsumoto, Yoshihiro [1 ]
机构
[1] Fukushima Med Univ, Sch Med, Dept Orthopaed Surg, Fukushima, Japan
[2] Fukushima Med Univ, Sch Med, Higashi Shirakawa Orthopaed Acad, Fukushima, Japan
[3] Fukushima Med Univ, Sch Med, Dept Diag Pathol, Fukushima, Japan
[4] Fukushima Med Univ, Sch Med, Dept Radiol, Fukushima, Japan
[5] Fukushima Med Univ Hosp, Dept Pediat Oncol, Fukushima, Japan
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
adipocytic tumor; atypical lipomatous tumor; lipoblastoma; child; murine double minute 2; MDM2; cyclin-dependent kinase 4; CDK4; DIFFERENTIATED LIPOSARCOMA;
D O I
10.3389/fonc.2024.1401861
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Atypical lipomatous tumors (ALTs) are locally aggressive adipocytic malignancies that frequently occur in middle-aged adults. We report the rare case of an ALT of the thigh that occurred in a 4-year-old girl. Since the tumor was initially diagnosed as a lipoblastoma by incisional biopsy, marginal resection was performed. Histopathological findings of the surgical specimen revealed the proliferation of mature and variously sized adipocytes, as well as ectopic ossification; these features differ from the typical findings of lipoblastoma. Immunohistochemical findings showed nuclear positivity for a murine double minute 2 (MDM2) and cyclin-dependent kinase 4 (CDK4) and negativity for pleomorphic adenoma gene 1 (PLAG1). Fluorescence in situ hybridization showed abnormal amplification of the MDM2 gene. The patient was thus finally diagnosed as having an ALT. No signs of local recurrence or metastasis were noted 1 year postoperatively. This case is instructive in the differential diagnosis of primary adipocytic tumors. Lipoblastomas are the most common adipocytic tumors in children, but if a tumor is located in the deep tissue or imaging findings are not typical, the possibility of ALT should be considered and immunohistochemistry for MDM2 and CDK4 should be added.
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页数:6
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