Chronic myeloid leukemia with involvement of membranous labyrinth

被引：0
作者：
El Kettani, Mobachir [1 ,2 ]
Shah, Kashish [1 ,2 ]
Farooq, Hareem [1 ,2 ]
Li, Ke [3 ]
Badar, Talha [1 ,2 ]
机构：
[1] Mayo Clinic, Div Hematol Oncol & Blood & Marrow Transplantat, Jacksonville, FL USA
[2] Mayo Clin, Cellular Therapy Program, Jacksonville, FL USA
[3] Mayo Clin, Dept Lab Med & Pathol, Jacksonville, FL USA
来源：
LEUKEMIA RESEARCH REPORTS | 2024年 / 22卷
关键词：
Chronic myeloid leukemia; T315i mutation; Blast crisis; Neurotological involvement; Tyrosine kinase inhibitors; atypical presentation; CHRONIC MYELOGENOUS LEUKEMIA; BLAST CRISIS; HEARING-LOSS;
D O I：
10.1016/j.lrr.2024.100471
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This case report explains an extraordinary presentation of chronic myeloid leukemia (CML) in a 39-year-old male with a T315I mutation, presenting with acute bilateral hearing loss and imbalance secondary to myeloid blast crisis. Neurological involvement was confirmed through MRI brain and cerebrospinal fluid analysis. Initial treatment with ponatinib and FLAG (fludarabine, cytarabine, G-CSF) regimen showed promise, but complications necessitated discontinuation. The patient's complex clinical trajectory, marked by complications and intolerance to tyrosine kinase inhibitors, highlights the intricate nature of CML blast crisis with T315I mutation management. Recognizing atypical presentations and early mutation analysis are pivotal for tailored treatment strategies.
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页数：4
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