The Protective Efficacy of a SARS-CoV-2 Vaccine Candidate B.1.351V against Several Variant Challenges in K18-hACE2 Mice

被引：0

作者：

Yang, Jie ^{[1
,2
,3
,4
]}

Fan, Huifen ^{[1
,2
,3
,4
]}

Yang, Anna ^{[1
,2
,3
,4
]}

Wang, Wenhui ^{[1
,2
,3
,4
]}

Wan, Xin ^{[1
,2
,3
,4
]}

Lin, Fengjie ^{[1
,2
,3
,4
]}

Yang, Dongsheng ^{[1
,2
,3
,4
]}

Wu, Jie ^{[1
,2
,3
,4
]}

Wang, Kaiwen ^{[1
,2
,3
,4
]}

Li, Wei ^{[1
,2
,3
,4
]}

Cai, Qian ^{[1
,2
,3
,4
]}

You, Lei ^{[1
,2
,3
,4
]}

Pang, Deqin ^{[1
,2
,3
,4
]}

Lu, Jia ^{[1
,2
,3
,4
]}

Guo, Changfu ^{[1
,2
,3
,4
]}

Shi, Jinrong ^{[1
,2
,3
,4
]}

Sun, Yan ^{[5
]}

Li, Xinguo ^{[1
,2
,3
,4
]}

Duan, Kai ^{[1
,2
,3
,4
]}

Shen, Shuo ^{[1
,2
,3
,4
]}

Meng, Shengli ^{[1
,2
,3
,4
]}

Guo, Jing ^{[1
,2
,3
,4
]}

Wang, Zejun ^{[1
,2
,3
,4
]}

机构：

[1] Wuhan Inst Biol Prod Co Ltd, Wuhan 430207, Peoples R China

[2] Natl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China

[3] Natl Key Lab Novel Vaccines Res & Dev Emerging Inf, Wuhan 430207, Peoples R China

[4] Hubei Prov Vaccine Technol Innovat Ctr, Wuhan 430207, Peoples R China

[5] South Cent Univ Nationalities, Wuhan Inst Neurosci & Neuroengn, Wuhan 430074, Peoples R China

来源：

VACCINES | 2024年 / 12卷 / 07期

关键词：

SARS-CoV-2; variants; vaccine; immunogenicity; protection; COVID-19; NEUTRALIZATION;

D O I：

10.3390/vaccines12070742

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The emergence of SARS-CoV-2 variants of concern (VOCs) with increased transmissibility and partial resistance to neutralization by antibodies has been observed globally. There is an urgent need for an effective vaccine to combat these variants. Our study demonstrated that the B.1.351 variant inactivated vaccine candidate (B.1.351V) generated strong binding and neutralizing antibody responses in BALB/c mice against the B.1.351 virus and other SARS-CoV-2 variants after two doses within 28 days. Immunized K18-hACE2 mice also exhibited elevated levels of live virus-neutralizing antibodies against various SARS-CoV-2 viruses. Following infection with these viruses, K18-hACE2 mice displayed a stable body weight, a high survival rate, minimal virus copies in lung tissue, and no lung damage compared to the control group. These findings indicate that B.1.351V offered protection against infection with multiple SARS-CoV-2 variants in mice, providing insights for the development of a vaccine targeting SARS-CoV-2 VOCs for human use.

引用

页数：14

共 50 条

[1] Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults A Randomized Clinical Trial [J].

Al Kaabi, Nawal ;

Zhang, Yuntao ;

Xia, Shengli ;

Yang, Yunkai ;

Al Qahtani, Manaf M. ;

Abdulrazzaq, Najiba ;

Al Nusair, Majed ;

Hassany, Mohamed ;

Jawad, Jaleela S. ;

Abdalla, Jehad ;

Hussein, Salah Eldin ;

Al Mazrouei, Shamma K. ;

Al Karam, Maysoon ;

Li, Xinguo ;

Yang, Xuqin ;

Wang, Wei ;

Lai, Bonan ;

Chen, Wei ;

Huang, Shihe ;

Wang, Qian ;

Yang, Tian ;

Liu, Yang ;

Ma, Rui ;

Hussain, Zaidoon M. ;

Khan, Tehmina ;

Saifuddin Fasihuddin, Mohammed ;

You, Wangyang ;

Xie, Zhiqiang ;

Zhao, Yuxiu ;

Jiang, Zhiwei ;

Zhao, Guoqing ;

Zhang, Yanbo ;

Mahmoud, Sally ;

ElTantawy, Islam ;

Xiao, Peng ;

Koshy, Ashish ;

Zaher, Walid Abbas ;

Wang, Hui ;

Duan, Kai ;

Pan, An ;

Yang, Xiaoming .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 326 (01) :35-45

[2] Omicron variant of SARS-CoV-2: Genomics, transmissibility, and responses to current COVID-19 vaccines [J].

Araf, Yusha ;

Akter, Fariya ;

Tang, Yan-dong ;

Fatemi, Rabeya ;

Parvez, Md Sorwer Alam ;

Zheng, Chunfu ;

Hossain, Md Golzar .

JOURNAL OF MEDICAL VIROLOGY, 2022, 94 (05) :1825-1832

[3] Omicron BA.1, BA.2 and COVID-19 Booster Vaccination [J].

Assawakosri, Suvichada ;

Kanokudom, Sitthichai ;

Suntronwong, Nungruthai ;

Puenpa, Jiratchaya ;

Duangchinda, Thaneeya ;

Chantima, Warangkana ;

Pakchotanon, Pattarakul ;

Mongkolsapaya, Juthathip ;

Wanlapakorn, Nasamon ;

Honsawek, Sittisak ;

Poovorawan, Yong .

JOURNAL OF INFECTIOUS DISEASES, 2022, 226 (08) :1480-1481

[4] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[5] Accelerated COVID-19 vaccine development: milestones, lessons, and prospects [J].

Bok, Karin ;

Sitar, Sandra ;

Graham, Barney S. ;

Mascola, John R. .

IMMUNITY, 2021, 54 (08) :1636-1651

[6] NOVAVAX OFFERS FIRST EVIDENCE THAT COVID VACCINES PROTECT PEOPLE AGAINST VARIANTS [J].

Callaway, Ewen ;

Mallapaty, Smriti .

NATURE, 2021, 590 (7844) :17-17

[7] A Bivalent Omicron-Containing Booster Vaccine against Covid-19 [J].

Chalkias, Spyros ;

Harper, Charles ;

Vrbicky, Keith ;

Walsh, Stephen R. ;

Essink, Brandon ;

Brosz, Adam ;

McGhee, Nichole ;

Tomassini, Joanne E. ;

Chen, Xing ;

Chang, Ying ;

Sutherland, Andrea ;

Montefiori, David C. ;

Girard, Bethany ;

Edwards, Darin K. ;

Feng, Jing ;

Zhou, Honghong ;

Baden, Lindsey R. ;

Miller, Jacqueline M. ;

Das, Rituparna .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (14) :1279-1291

[8] Current evidence on efficacy of COVID-19 booster dose vaccination against the Omicron variant: A systematic review [J].

Chenchula, Santenna ;

Karunakaran, Padmavathi ;

Sharma, Sushil ;

Chavan, Madhavrao .

JOURNAL OF MEDICAL VIROLOGY, 2022, 94 (07) :2969-2976

[9] Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination [J].

Cheng, Samuel M. S. ;

Mok, Chris Ka Pun ;

Leung, Yonna W. Y. ;

Ng, Susanna S. ;

Chan, Karl C. K. ;

Ko, Fanny W. ;

Chen, Chunke ;

Yiu, Karen ;

Lam, Bosco H. S. ;

Lau, Eric H. Y. ;

Chan, Ken K. P. ;

Luk, Leo L. H. ;

Li, John K. C. ;

Tsang, Leo C. H. ;

Poon, Leo L. M. ;

Hui, David S. C. ;

Peiris, Malik .

NATURE MEDICINE, 2022, 28 (03) :486-+

[10] COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection [J].

Chi, Wei-Yu ;

Li, Yen-Der ;

Huang, Hsin-Che ;

Chan, Timothy En Haw ;

Chow, Sih-Yao ;

Su, Jun-Han ;

Ferrall, Louise ;

Hung, Chien-Fu ;

Wu, T-C .

JOURNAL OF BIOMEDICAL SCIENCE, 2022, 29 (01)

← 1 2 3 4 5 →