A new cassane diterpenoid from the seed of Caesalpinia sappan

被引：0

作者：

Zhao, Yue-Lin ^{[1
,2
,3
]}

Jin, Yue ^{[1
,2
,3
]}

Han, Zi-Ying ^{[1
,2
,3
]}

Song, Wen-Han ^{[1
,2
,3
]}

Zhu, Hui-Lin ^{[1
,2
,3
]}

Zhang, Jian ^{[1
,2
,3
]}

Wang, Qian ^{[1
,2
,3
]}

Wang, Miao ^{[1
,2
,3
]}

Jiang, Xiao-Wen ^{[1
,2
,3
]}

Gao, Hui-Yuan ^{[1
,2
,3
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Key Lab Pharmacodynam Subst Res & Translat Med Imm, Shenyang 110016, Peoples R China

[3] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2024年

基金：

中国国家自然科学基金;

关键词：

cassane diterpenoid; Caesalpinia sappan; anti-neuroinflammation; BV2; cells; KERNELS; LEAVES;

D O I：

10.1080/10286020.2024.2360640

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (1), along with two known cassane diterpenoids caesanine C (2) and tomocinol B (3), was isolated from 95% EtOH extract of the seeds of Caesalpinia sappan Linn. Additionally, three known compounds including pulcherrin R (4), syringaresinol-4'-O-beta-D-glucopyranoside (5) and kaempferol (6) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound 1. Among the isolated compounds, compound 1 displayed a potent anti-neuroinflammation with an IC50 value of 9.87 +/- 1.71 mu M. [GRAPHICS]

引用

页数：7

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