Therapeutic plasma exchange for hyperviscosity syndrome in IgA multiple myeloma

被引：0

作者：

Yurtsever, Nalan ^{[1
]}

Binns, Thomas C. ^{[1
]}

Hendrickson, Jeanne E. ^{[2
,3
]}

Tormey, Christopher A. ^{[1
]}

Lee, Edward S. ^{[1
]}

机构：

[1] Yale Sch Med, Dept Lab Med, New Haven, CT 06510 USA

[2] Emory Univ, Dept Pathol & Lab Med, Sch Med, Atlanta, GA USA

[3] Childrens Healthcare Atlanta, Atlanta, GA USA

来源：

LABORATORY MEDICINE | 2024年 / 56卷 / 01期

关键词：

hyperviscosity; plasmapheresis; plasma exchange; IgA; IgG; REMOVAL; IMMUNOGLOBULIN; PATIENT;

D O I：

10.1093/labmed/lmae054

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Hyperviscosity syndrome (HVS) is defined as the symptomatic presentation of increased blood thickness due to various clinical conditions such as hypergammaglobulinemia. HVS secondary to immunoglobulin (Ig)A multiple myeloma has been infrequently reported. Although the efficiency of IgM or IgG removal by therapeutic plasma exchange (TPE) is well described, the efficiency of IgA removal by TPE is not as well known. Here, we describe a case of HVS due to IgA myeloma in a patient who received 2 TPE treatments, with subsequent symptomatic improvement as well as decrease in IgA and viscosity levels.

引用

页码：85 / 88

页数：4

共 29 条

[1]

ALKNER U, 1983, CLIN EXP IMMUNOL, V51, P617

[2] Ixazomib Treatment of IgA Multiple Myeloma With Hyperviscosity Syndrome [J].

Boiten, Henk-Jan ;

Buijze, Michiel ;

Zweegman, Sonja ;

Levin, Mark-David .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2020, 20 (11) :E832-E835

[3] Guidelines on the Use of Therapeutic Apheresis in Clinical Practice - Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Ninth Special Issue [J].

Connelly-Smith, Laura ;

Alquist, Caroline R. ;

Aqui, Nicole A. ;

Hofmann, Jan C. ;

Klingel, Reinhard ;

Onwuemene, Oluwatoyosi A. ;

Patriquin, Christopher J. ;

Pham, Huy P. ;

Sanchez, Amber P. ;

Schneiderman, Jennifer ;

Witt, Volker ;

Zantek, Nicole D. ;

Dunbar, Nancy M. .

JOURNAL OF CLINICAL APHERESIS, 2023, 38 (02) :77-278

[4] PLASMAPHERESIS IN A PATIENT WITH RAPIDLY PROGRESSIVE IDIOPATHIC IGA NEPHROPATHY - REMOVAL OF IGA-CONTAINING CIRCULATING IMMUNE-COMPLEXES AND CLINICAL RECOVERY [J].

COPPO, R ;

BASOLO, B ;

GIACHINO, O ;

ROCCATELLO, D ;

LAJOLO, D ;

MAZZUCCO, G ;

AMORE, A ;

PICCOLI, G .

NEPHRON, 1985, 40 (04) :488-490

[5]

DERKSEN RHWM, 1984, J LAB CLIN MED, V104, P346

[6] HYPERVISCOSITY SYNDROME WITH LGA MYELOMA [J].

DINE, ME ;

GUAY, AT ;

SNYDER, LM .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1972, 264 (02) :111-&

[7] Immunomodulatory Aspects of Therapeutic Plasma Exchange in Neurological Disorders-A Pilot Study [J].

Foettinger, Fabian ;

Pilz, Georg ;

Wipfler, Peter ;

Harrer, Andrea ;

Kern, Jan Marco ;

Trinka, Eugen ;

Moser, Tobias .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (07)

[8]

Frimmel S, 2022, NEPHROL DIAL TRANSPL, V37, pI98, DOI 10.1093/ndt/gfac066.063

[9] Dexamethasone implant for immunogammopathy maculopathy associated with IgA multiple myeloma [J].

Georgakopoulos, Constantine D. ;

Plotas, Panagiotis ;

Angelakis, Angelos ;

Kagkelaris, Konstantinos ;

Tzouvara, Evangelia ;

Makri, Olga E. .

THERAPEUTIC ADVANCES IN OPHTHALMOLOGY, 2019, 11

[10] Acute hyperviscosity: syndromes and management [J].

Gertz, Morie A. .

BLOOD, 2018, 132 (13) :1379-1385

← 1 2 3 →