Short-chain fatty acids: bridges between diet, gut microbiota, and health

被引：26

作者：

Wang, Ling-Yun ^{[1
,2
]}

He, Li-Hong ^{[2
,3
]}

Xu, Li-Jun ^{[4
]}

Li, Shi-Bo ^{[1
]}

机构：

[1] Zhejiang Univ, Zhoushan Hosp, Dept Infect Dis, Zhoushan 316021, Peoples R China

[2] Zhejiang Univ, Coll Med, Hangzhou, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou, Peoples R China

[4] Zhejiang Univ, Affiliated Hosp 1, Coll Med, State Key Lab Diag & Treatment Infect Dis, 79 Qingchun Rd, Hangzhou 310003, Peoples R China

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2024年 / 39卷 / 09期

关键词：

gut microbiota; immune; inflammation; metabolism; SCFAs; METABOLITE BUTYRATE; FIBER; BACTERIAL; PROPIONATE; ACETYLATION; ACTIVATION; PREBIOTICS; INHIBITION; INDUCE; TARGET;

D O I：

10.1111/jgh.16619

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In recent years, gut microbiota has become a hot topic in the fields of medicine and life sciences. Short-chain fatty acids (SCFAs), the main metabolites of gut microbiota produced by microbial fermentation of dietary fiber, play a vital role in healthy and ill hosts. SCFAs regulate the process of metabolism, immune, and inflammation and have therapeutic effects on gastrointestinal and neurological disorders, as well as antitumor properties. This review summarized the production, distribution, and molecular mechanism of SCFAs, as well as their mechanisms of action in healthy and ill hosts. In addition, we also emphasized the negative effects of SCFAs, aiming to provide the public with a more comprehensive understanding of SCFAs.

引用

页码：1728 / 1736

页数：9

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