Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis

被引：0

作者：

Wang, Tianyu ^{[1
,2
]}

Li, Lichen ^{[1
,2
]}

Cao, Shan ^{[1
,2
]}

Sun, Lele ^{[1
,2
]}

Yu, Gongqi ^{[1
,2
]}

Xia, Qianqian ^{[1
,2
]}

Liu, Tingting ^{[1
,2
]}

Zhao, Qing ^{[1
,2
]}

Wang, Zhenzhen ^{[1
,2
]}

Wang, Chuan ^{[1
,2
]}

Yang, Baoqi ^{[1
,2
]}

Liu, Yongxia ^{[1
,2
]}

Chen, Xuechao ^{[1
,2
]}

Chen, Shengli ^{[1
,2
]}

Zhou, Guizhi ^{[1
,2
]}

Liu, Hong ^{[1
,2
,3
]}

Sun, Yonghu ^{[1
,2
,3
]}

Zhang, Furen ^{[3
]}

机构：

[1] Shandong First Med Univ, Hosp Skin Dis, Jinan, Shandong, Peoples R China

[2] Shandong Acad Med Sci, Shandong Prov Inst Dermatol & Venereol, Jinan, Shandong, Peoples R China

[3] Natl Clin Key Project Dermatol & Venereol, Jinan, Shandong, Peoples R China

来源：

CLINICAL IMMUNOLOGY | 2024年 / 265卷

基金：

中国国家自然科学基金;

关键词：

Linear IgA bullous dermatosis; Dermatitis herpetiformis; Proteomics; NADPH; Neutrophil; NCF2; NADPH OXIDASE; DIAGNOSIS; ACTIN; BINDING; DERMATOSIS; EXPRESSION; GUIDELINES; PROTEINS; FEATURES; COMPLEX;

D O I：

10.1016/j.clim.2024.110291

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Linear IgA bullous dermatosis (LABD) and dermatitis herpetiformis (DH) represent the major subtypes of IgA mediated autoimmune bullous disorders. We sought to understand the disease etiology by using serum proteomics. We assessed 92 organ damage biomarkers in LABD, DH, and healthy controls using the Olink highthroughput proteomics. The positive proteomic serum biomarkers were used to correlate with clinical features and HLA type. Targeted proteomic analysis of IgA deposition bullous disorders vs. controls showed elevated biomarkers. Further clustering and enrichment analyses identified distinct clusters between LABD and DH, highlighting the involvement of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Comparative analysis revealed biomarkers with distinction between LABD and DH and validated in the skin lesion. Finally, qualitative correlation analysis with DEPs suggested six biomarkers (NBN, NCF2, CAPG, FES, BID, and PXN) have better prognosis in DH patients. These findings provide potential biomarkers to differentiate the disease subtype of IgA deposition bullous disease.

引用

页数：9