Oxidative C-N Bond Formation of Isochromans Using an Electronically Tuned Nitroxyl Radical as Catalyst

被引：0

作者：

Yano, Kyoko ^{[1
]}

Ohshimo, Ayano ^{[1
]}

Elboray, Elghareeb E. ^{[1
,2
]}

Kobayashi, Yusuke ^{[1
]}

Furuta, Takumi ^{[1
]}

Hamada, Shohei ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Lab Pharmaceut Chem, Yamashinaku, Kyoto 6078412, Japan

[2] South Valley Univ, Fac Sci, Dept Chem, Qena 83523, Egypt

来源：

SYNOPEN | 2024年 / 08卷 / 02期

关键词：

isochroman; cross-dehydrogenative coupling; nitroxyl radical; C-N bond formation; organocatalyst; oxidation; H BONDS; CHEMOSELECTIVE OXIDATION; AEROBIC OXIDATION; ETHERS; ALCOHOLS; TEMPO; MILD;

D O I：

10.1055/s-0040-1720118

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cross-dehydrogenative coupling between isochromansand nucleophiles using an electronically tuned nitroxyl radical catalyst,which effectively promotes the oxidation of benzylic ethers, has beeninvestigated. Using sulfonamides as a nucleophile, modification of isochromans via oxidative C-N bond formation has been achieved at ambient temperature.

引用

页码：125 / 129

页数：5

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