Acute Myeloid Leukemia and Next-Generation Sequencing Panels for Diagnosis: A Comprehensive Review

被引：1

作者：

Chaudhary, Spandan ^{[1
]}

Chaudhary, Pooja ^{[1
]}

Ahmad, Firoz ^{[1
]}

Arora, Neeraj ^{[1
]}

机构：

[1] Unipath Specialty Lab Ltd, Ahmadabad, Gujarat, India

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2024年 / 46卷 / 03期

关键词：

AML; ELN2022; biomarkers; fusions; NGS panels; WORLD-HEALTH-ORGANIZATION; MYELODYSPLASTIC SYNDROMES; EPIGENETIC MODIFIERS; RISK-STRATIFICATION; PROGNOSTIC IMPACT; DNMT3A MUTATIONS; ADULT PATIENTS; CLASSIFICATION; AML; NEOPLASMS;

D O I：

10.1097/MPH.0000000000002840

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized by the accumulation of acquired somatic genetic alterations in hematopoietic progenitor cells, which alter the normal mechanisms of self-renewal, proliferation, and differentiation. Due to significant technological advancements in sequencing technologies in the last 2 decades, classification and prognostic scoring of AML has been refined, and multiple guidelines are now available for the same. The authors have tried to summarize, latest guidelines for AML diagnosis, important markers associated, epigenetics markers, various AML fusions and their importance, etc. Review of literature suggests lack of study or comprehensive information about current NGS panels for AML diagnosis, genes and fusions covered, their technical know-how, etc. To solve this issue, the authors have tried to present detailed review about currently in use next-generation sequencing myeloid panels and their offerings.

引用

页码：125 / 137

页数：13

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