A tea polyphenol-loaded cellulose/silk fibroin/polyacrylic acid hydrogel for wound healing

被引：5

作者：

Liu, Huijun ^{[1
,2
]}

Chen, Li ^{[1
,2
]}

Peng, Yan ^{[1
,2
]}

Li, Xia ^{[1
,2
]}

Zhang, Haiqiang ^{[1
,2
]}

Chen, Yanhao ^{[1
,2
]}

Li, Zhi ^{[1
,2
]}

Dai, Fangyin ^{[1
,2
]}

机构：

[1] Southwest Univ, Coll Sericulture Text & Biomass Sci, Engn Res Ctr Biomat Fiber & Modern Text, Chongqing 400715, Peoples R China

[2] Southwest Univ, State Key Lab Resource Insects, Chongqing 400715, Peoples R China

来源：

CELLULOSE | 2024年 / 31卷 / 13期

关键词：

Cellulose silk fibroin; Hydrogel; Antimicrobial property; Tea polyphenols; Wound dressing; SILK FIBROIN; ANTIBACTERIAL ACTIVITY; SILVER NANOPARTICLES; SCAFFOLD; BIONANOCOMPOSITE; MEMBRANES; CATALYST;

D O I：

10.1007/s10570-024-06102-5

中图分类号：

TB3 [工程材料学]; TS [轻工业、手工业、生活服务业];

学科分类号：

0805 ; 080502 ; 0822 ;

摘要：

Hydrogels can relieve wound pain and provide a moist environment for wound healing. Although hydrogels based on natural materials have proven to be biocompatible and biodegradable, their antibacterial and anti-inflammatory properties are not desirable. Natural extracts with antimicrobial and antioxidant properties are becoming increasingly attractive because of their environmentally friendly nature and good biocompatibility. Herein, composite cellulose/silk fibroin/polyacrylic acid hydrogels based on natural materials were fabricated by crosslinking between oxidized cellulose and silk fibroin together with radical polymerization of acrylic acid. The fabricated hydrogels displayed a uniform hierarchical topography with high porosity, as well as good mechanical properties, swelling properties, air permeability and biocompatibility. With the addition of tea polyphenols to natural extracts, the composite hydrogels exhibited significant antimicrobial and antioxidant properties such that they could prevent bacterial infection and relieve wound inflammation in the inflammation stage and could promote the synthesis of extracellular matrix (ECM), angiogenesis, collagenization and re-epithelization during wound healing. The tea polyphenols/cellulose/silk fibroin/polyacrylic acid hydrogels fabricated in this study can accelerate wound healing, demonstrating their great potential for application in wound dressings.

引用

页码：8169 / 8187

页数：19

共 66 条

[1] Artemisinin-loaded silk fibroin/gelatin composite hydrogel for wound healing and tumor therapy [J].