ADIPOKINES AND THEIR ROLE IN ACUTE PANCREATITIS

被引：5

作者：

Rafaqat, Saira ^{[1
]}

Vujacic, Irena Radoman ^{[2
]}

Patoulias, Dimitrios ^{[3
]}

Khurshid, Huma ^{[1
]}

Klisic, Aleksandra ^{[4
,5
]}

机构：

[1] Lahore Coll Women Univ, Dept Zool, Lahore, Punjab, Pakistan

[2] Univ Montenegro, Fac Med, Clin Ctr Montenegro, Dept Internal Med, Podgorica, Montenegro

[3] Aristotle Univ Thessaloniki, Gen Hosp Hippokrat, Outpatient Dept Cardiometab Med, Dept Cardiol 2, Thessaloniki, Greece

[4] Univ Montenegro, Fac Med, Podgorica, Montenegro

[5] Primary Hlth Care Ctr, Ctr Lab Diagnost, Podgorica, Montenegro

来源：

JOURNAL OF MEDICAL BIOCHEMISTRY | 2024年 / 43卷 / 04期

关键词：

acute pancreatitis; adipokines; adipose tissue; obesity; GELATINASE-ASSOCIATED LIPOCALIN; RETINOL-BINDING-PROTEIN; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; EARLY PREDICTOR; PERIPANCREATIC NECROSIS; ORGAN FAILURE; SEVERITY; OSTEOPONTIN; INFLAMMATION;

D O I：

10.5937/jomb0-47515

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute pancreatitis (AP) is characterized by an inflammatory response that leads to edema and haemorrhaging of pancreatic tissue. In severe cases, it can even result in the necrosis of pancreatic tissue following activation within the pancreas. Adipokines are biologically active molecules released by adipose tissue that have a wide-ranging impact on health and disease. Adipokines are cytokines produced not only in white adipose tissue but also in the fat surrounding the pancreas, and they play a role in the body's inflammatory response. The presence of increased adipose tissue, often associated with obesity, has been linked to a heightened systemic inflammatory response in cases of AP. According to the literature, there are many adipokines. This article summarizes the role of adipokines in AP. Adipokines could be promising biomarkers for both diagnostic and new therapeutic treatment strategies in AP. However, a deeper knowledge of the signaling pathways of adipokines and their potential therapeutic role in AP is necessary.

引用

页码：512 / 527

页数：16

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