Transdermal delivery of elastin peptide assisted by betaine-based deep eutectic solvent to ameliorate skin photoaging

被引:2
作者
Bai, De [1 ,2 ,3 ]
Wang, Zhenyuan [5 ]
Xiao, Yuan [4 ]
Liu, Tianqi [1 ,2 ,3 ]
Pu, Yan [4 ]
Sun, Huaiqing [4 ]
Wang, Mi [1 ,2 ,3 ]
Guo, Chaowan [4 ]
Zhang, Jiaheng [1 ,2 ,3 ,5 ]
机构
[1] Harbin Inst Technol, Sauvage Lab Smart Mat, Shenzhen 518055, Peoples R China
[2] Harbin Inst Technol, State Key Lab Adv Welding & Joining, Shenzhen 518055, Peoples R China
[3] Harbin Inst Technol, Res Ctr Printed Flexible Elect, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
[4] Guangdong Marubi Biotechnol Co Ltd, Guangzhou 510700, Peoples R China
[5] Shenzhen Shinehigh Innovat Technol LTD, Shenzhen 518055, Peoples R China
来源
BIOMATERIALS ADVANCES | 2024年 / 163卷
基金
中国国家自然科学基金;
关键词
Elastin peptide; Deep eutectic solvents; Transdermal delivery; Skin barrier repair; Anti-wrinkle; OXIDATIVE STRESS;
D O I
10.1016/j.bioadv.2024.213965
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
The unique amino acid composition of elastin peptide (EP) makes it an excellent resource to obtain antioxidant peptides. It exhibits high elastase inhibitory activity with the potential to resist skin aging and is currently used in a many cosmetic products. However, the inherent low permeability of the skin limits its ability to penetrate the skin. To address this issue, a deep eutectic solvent (SAB) with excellent bioactivity was synthesized from betaine and succinic acid and used as a permeation enhancer to improve the absorption and utilization of EP in this paper. The results showed that low SAB concentrations significantly increased the transdermal delivery of EP. The 3D epidermal skin model (EpiKutis (R)) demonstrated that SAB/EP induced the synthesis of hyaluronic acid (HA) and filaggrin (FLG), accelerated skin barrier repair, and reduced water loss. Additionally, the zebrafish embryonic model showed that SAB/EP could reduce melanin secretion, decrease melanin deposition, and have an ameliorative effect on skin photoaging. Cellular experiments proved that SAB/EP can stimulate human skin fibroblasts to secrete procollagen I and elastin, improving skin elasticity and anti-wrinkle. The combination of EP and DES is a new attempt that is expected to be used as a safe and effective anti-wrinkle cosmetic material.
引用
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页数:11
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