Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Cases

被引：3

作者：

Brizuela, Claudia ^{[1
,3
]}

Meza, Gaston ^{[1
]}

Khoury, Maroun ^{[2
]}

机构：

[1] Univ Los Andes, Fac Dent, Ctr Act Biosilicate Technol TM Invest Biol & Regen, Santiago, Chile

[2] Univ Los Andes, Fac Med, Lab Nanoregenerat Med, Santiago, Chile

[3] Univ Los Andes, Fac Dent, Alvaro del Portillo 12 455, Santiago 7620001, Chile

来源：

JOURNAL OF ENDODONTICS | 2024年 / 50卷 / 05期

关键词：

Apical periodontitis; mature teeth; mesenchymal stem cell transplantation; platelet-poor plasma; regenerative medicine; MESENCHYMAL STEM-CELLS; PERIODONTITIS; PULPITIS; THERAPY; TISSUE; TOOTH;

D O I：

10.1016/j.joen.2024.02.012

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Introduction: Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth. Methods: Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis. Results: After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization. Conclusions: This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios. (J Endod 2024;50:596-601.)

引用

页码：596 / 601

页数：6

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