Clostridioides difficile Infection in the Elderly: Trend Analysis from 2000 to 2019

被引：0

作者：

Danpanichkul, Pojsakorn ^{[1
,2
]}

Duangsonk, Kwanjit ^{[3
]}

Uawithya, Ekdanai ^{[4
]}

Kongarin, Siwanart ^{[5
]}

Simadibrata, Daniel M. ^{[6
,7
]}

Polpichai, Natchaya ^{[8
]}

Suenghataiphorn, Thanathip ^{[9
]}

Wattanachayakul, Phuuwadith ^{[10
]}

Pang, Yanfang ^{[11
,12
]}

Sukphutanan, Banthoon ^{[5
]}

Kaewdech, Apichat ^{[13
]}

Panpradist, Nuttada ^{[14
]}

Chaiyakunapruk, Nathorn ^{[15
,16
]}

Pupaibool, Jakrapun ^{[17
]}

Wijarnpreecha, Karn ^{[18
,19
,20
]}

机构：

[1] Texas Tech Univ Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USA

[2] Chiang Mai Univ, Fac Med, Dept Microbiol, Immunol Unit, Chiang Mai 50200, Thailand

[3] Chiang Mai Univ, Fac Med, Dept Microbiol, Chiang Mai 50200, Thailand

[4] Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok 10700, Thailand

[5] Chiang Mai Univ, Fac Med, Chiang Mai 50200, Thailand

[6] Univ Indonesia, Fac Med, Depok 16424, Indonesia

[7] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

[8] Weiss Mem Hosp, Dept Internal Med, Chicago, IL 60640 USA

[9] Griffin Hosp, Dept Internal Med, Derby, CT 06460 USA

[10] Albert Einstein Healthcare Network, Dept Med, Philadelphia, PA 19144 USA

[11] Youjiang Med Univ Nationalities, Affiliated Hosp, Baise 533000, Guangxi, Peoples R China

[12] Natl Immunol Lab Tradit Chinese Med, Baise 533000, Guangxi, Peoples R China

[13] Prince Songkla Univ, Fac Med, Div Internal Med, Gastroenterol & Hepatol Unit, Hat Yai 90110, Thailand

[14] Univ Washington, Global Ctr Integrated Hlth Women Adolescents & Chi, Dept Global Hlth, Seattle, WA 98195 USA

[15] Univ Utah, Coll Pharm, Dept Pharmacotherapy, Salt Lake City, UT 84112 USA

[16] Vet Affairs Salt Lake City Healthcare Syst, IDEAS Ctr, Salt Lake City, UT 84148 USA

[17] Univ Utah, Sch Med, Dept Internal Med, Div Infect Dis, Salt Lake City, UT 84113 USA

[18] Univ Arizona, Coll Med, Dept Med, Div Gastroenterol & Hepatol, Phoenix, AZ 85004 USA

[19] Banner Univ, Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol, Phoenix, AZ 85724 USA

[20] Univ Arizona, BIO5 Inst, Coll Med, Phoenix, AZ 85004 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2024年 / 13卷 / 13期

关键词：

Clostridioides difficile; Clostridium difficile; epidemiology; geriatrics; elderly; infection; GENDER-DIFFERENCES; BURDEN; PREVENTION; COMMUNITY; DISEASE; IMPACT; HOST; RISK;

D O I：

10.3390/jcm13133740

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Objective: Clostridioides difficile infection (CDI) is a common healthcare-associated ailment, presenting major health and economic challenges, especially for the elderly. Despite its prevalence, comprehensive data about CDI's impact on the elderly are limited. Methods: This study used the Global Burden of Disease Study 2019 data to analyze CDI trends from 2000 to 2019, considering factors like sex, region, and sociodemographic index (SDI). Results: This study revealed that CDI caused approximately 18,181 deaths and 252,709 disability-adjusted life years (DALYs) among the elderly worldwide. The Americas showed the highest CDI burden, while the Eastern Mediterranean saw the steepest rate increase from 2000 to 2019. Regions with a high SDI also displayed substantial CDI impact. Conclusions: The escalating burden of CDI in the elderly, especially in high-SDI areas and the Americas, emphasizes an urgent need for targeted public health strategies.

引用

页数：11

共 45 条

[1]

Abbafati C, 2020, LANCET, V396, P1204

[2] Clostridioides difficile infection: a changing treatment paradigm [J].