Feasibility and safety of contrast-enhanced magnetic resonance-guided adaptive radiotherapy for upper abdominal tumors: A preliminary exploration

被引：2
作者：
Jiang, Wenheng [1 ,2 ]
Shi, Xihua [3 ]
Zhang, Xiang [2 ]
Li, Zhenjiang [3 ]
Yue, Jinbo [2 ]
机构：
[1] Shandong First Med Univ & Shandong Acad Med Sci, Dept Grad, Jinan, Peoples R China
[2] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan, Peoples R China
[3] Shandong First Med Univ & Shandong Acad Med Sci, Dept Radiat Phys, Shandong Canc Hosp & Inst, Jinan, Peoples R China
来源：
PHYSICS & IMAGING IN RADIATION ONCOLOGY | 2024年 / 30卷
基金：
中国国家自然科学基金;
关键词：
MRgRT; MR-Linac; Upper abdominal tumor; MRI Contrast agent; Gadoterate meglumine; BODY RADIATION-THERAPY; GADOTERATE MEGLUMINE; MRI; DIAGNOSIS; AGENTS;
D O I：
10.1016/j.phro.2024.100582
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study investigates the use of contrast-enhanced magnetic resonance (MR) in MR-guided adaptive radiotherapy (MRgART) for upper abdominal tumors. Contrast-enhanced T1-weighted MR (cT1w MR) using half doses of gadoterate was used to guide daily adaptive radiotherapy for tumors poorly visualized without contrast. The use of gadoterate was found to be feasible and safe in 5-fraction MRgART and could improve the contrast-tonoise ratio of MR images. And the use of cT1w MR could reduce the interobserver variation of adaptive tumor delineation compared to plain T1w MR (4.41 vs. 6.58, p < 0.001) and T2w MR (4.41 vs. 7.42, p < 0.001).
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页数：5
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