Revolutionizing tumor immunotherapy: unleashing the power of progenitor exhausted T cells

被引：6

作者：

Fang, Zhang ^{[1
,2
,3
]}

Ding, Xinyi ^{[1
,2
,3
]}

Huang, Hao ^{[1
,2
,3
]}

Jiang, Hongwei ^{[1
,2
,3
]}

Jiang, Jingting ^{[1
,2
,3
]}

Zheng, Xiao ^{[1
,2
,3
]}

机构：

[1] Soochow Univ, Affiliated Hosp 3, Dept Tumor Biol Treatment, Changzhou 213003, Peoples R China

[2] Soochow Univ, Affiliated Hosp 3, Jiangsu Engn Res Ctr Tumor Immunotherapy, Changzhou 213003, Peoples R China

[3] Soochow Univ, Affiliated Hosp 3, Inst Cell Therapy, Changzhou 213003, Peoples R China

来源：

CANCER BIOLOGY & MEDICINE | 2024年 / 21卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Progenitor exhausted CD8+T cells; TCF-1; immunotherapy; tumor microenvironment; cellular crosstalk; CHRONIC INFECTION; CANCER; DYSFUNCTION; MAINTAIN; THERAPY; SUBSETS; DIFFERENTIATION; RESPONSES; IMMUNITY;

D O I：

10.20892/j.issn.2095-3941.2024.0105

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In exploring persistent infections and malignancies, a distinctive subgroup of CD8+ T cells, progenitor exhausted CD8+ T (Tpex) cells, has been identified. These Tpex cells are notable for their remarkable self-renewal and rapid proliferation abilities. Recent strides in immunotherapy have demonstrated that Tpex cells expand and differentiate into responsive exhausted CD8+ T cells, thus underscoring their critical role in the immunotherapeutic retort. Clinical examinations have further clarified a robust positive correlation between the proportional abundance of Tpex cells and enhanced clinical prognosis. Tpex cells have found noteworthy applications in the formulation of inventive immunotherapeutic approaches against tumors. This review describes the functions of Tpex cells in the tumor milieu, particularly their potential utility in tumor immunotherapy. Precisely directing Tpex cells may be essential to achieving successful outcomes in immunotherapy against tumors.

引用

页码：499 / 512

页数：14

共 111 条

[21] T cell factor 1: A master regulator of the T cell response in disease [J].

Escobar, Giulia ;

Mangani, Davide ;

Anderson, Ana C. .

SCIENCE IMMUNOLOGY, 2020, 5 (53)

[22]

Fehleisen F., 1882, Dtsch Med Wochenschr, V8, P553, DOI DOI 10.1055/S-0029-1196806

[23] Interleukin-15 and cancer: some solved and many unsolved questions [J].

Fiore, Piera Filomena ;

Di Matteo, Sabina ;

Tumino, Nicola ;

Mariotti, Francesca Romana ;

Pietra, Gabriella ;

Ottonello, Selene ;

Negrini, Simone ;

Bottazzi, Barbara ;

Moretta, Lorenzo ;

Mortier, Erwan ;

Azzarone, Bruno .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (02)

[24] Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours [J].

Flugel, Christian L. ;

Majzner, Robbie G. ;

Krenciute, Giedre ;

Dotti, Gianpietro ;

Riddell, Stanley R. ;

Wagner, Dimitrios L. ;

Abou-el-Enein, Mohamed .

NATURE REVIEWS CLINICAL ONCOLOGY, 2023, 20 (01) :49-62

[25] New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function [J].

Fu, Shin-Huei ;

Yeh, Li-Tzu ;

Chu, Chin-Chen ;

Yen, B. Lin-Ju ;

Sytwu, Huey-Kang .

JOURNAL OF BIOMEDICAL SCIENCE, 2017, 24

[26] PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors [J].

Gill, Amanda L. ;

Wang, Peter H. ;

Lee, Judong ;

Hudson, William H. ;

Ando, Satomi ;

Araki, Koichi ;

Hu, Yinghong ;

Wieland, Andreas ;

Im, Sejin ;

Gavora, Autumn ;

Medina, Christopher B. ;

Freeman, Gordon J. ;

Hashimoto, Masao ;

Reiner, Steven L. ;

Ahmed, Rafi .

SCIENCE IMMUNOLOGY, 2023, 8 (86)

[27] IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors [J].

Giuffrida, Lauren ;

Sek, Kevin ;

Henderson, Melissa A. ;

House, Imran G. ;

Lai, Junyun ;

Chen, Amanda X. Y. ;

Todd, Kirsten L. ;

Petley, Emma, V ;

Mardiana, Sherly ;

Todorovski, Izabela ;

Gruber, Emily ;

Kelly, Madison J. ;

Solomon, Benjamin J. ;

Vervoort, Stephin J. ;

Johnstone, Ricky W. ;

Parish, Ian A. ;

Neeson, Paul J. ;

Kats, Lev M. ;

Darcy, Phillip K. ;

Beavis, Paul A. .

MOLECULAR THERAPY, 2020, 28 (11) :2379-2393

[28] Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity [J].

Guo, Jingya ;

Liang, Yong ;

Xue, Diyuan ;

Shen, Jiao ;

Cai, Yueqi ;

Zhu, Jiankun ;

Fu, Yang-Xin ;

Peng, Hua .

CELL RESEARCH, 2021, 31 (11) :1190-1198

[29] Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity [J].

Guo, Yugang ;

Xie, Yu-Qing ;

Gao, Min ;

Zhao, Yang ;

Franco, Fabien ;

Wenes, Mathias ;

Siddiqui, Imran ;

Bevilacqua, Alessio ;

Wang, Haiping ;

Yang, Hanshuo ;

Feng, Bing ;

Xie, Xin ;

Sabatel, Catherine M. ;

Tschumi, Benjamin ;

Chaiboonchoe, Amphun ;

Wang, Yuxi ;

Li, Weimin ;

Xiao, Weihua ;

Held, Werner ;

Romero, Pedro ;

Ho, Ping-Chih ;

Tang, Li .

NATURE IMMUNOLOGY, 2021, 22 (06) :746-+

[30] Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo [J].

Hanna, B. S. ;

McClanahan, F. ;

Yazdanparast, H. ;

Zaborsky, N. ;

Kalter, V. ;

Roessner, P. M. ;

Benner, A. ;

Duerr, C. ;

Egle, A. ;

Gribben, J. G. ;

Lichter, P. ;

Seiffert, M. .

LEUKEMIA, 2016, 30 (03) :570-579

← 1 2 3 4 5 6 7 8 9 10 →