Revolutionizing tumor immunotherapy: unleashing the power of progenitor exhausted T cells

被引：6

作者：

Fang, Zhang ^{[1
,2
,3
]}

Ding, Xinyi ^{[1
,2
,3
]}

Huang, Hao ^{[1
,2
,3
]}

Jiang, Hongwei ^{[1
,2
,3
]}

Jiang, Jingting ^{[1
,2
,3
]}

Zheng, Xiao ^{[1
,2
,3
]}

机构：

[1] Soochow Univ, Affiliated Hosp 3, Dept Tumor Biol Treatment, Changzhou 213003, Peoples R China

[2] Soochow Univ, Affiliated Hosp 3, Jiangsu Engn Res Ctr Tumor Immunotherapy, Changzhou 213003, Peoples R China

[3] Soochow Univ, Affiliated Hosp 3, Inst Cell Therapy, Changzhou 213003, Peoples R China

来源：

CANCER BIOLOGY & MEDICINE | 2024年 / 21卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Progenitor exhausted CD8+T cells; TCF-1; immunotherapy; tumor microenvironment; cellular crosstalk; CHRONIC INFECTION; CANCER; DYSFUNCTION; MAINTAIN; THERAPY; SUBSETS; DIFFERENTIATION; RESPONSES; IMMUNITY;

D O I：

10.20892/j.issn.2095-3941.2024.0105

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In exploring persistent infections and malignancies, a distinctive subgroup of CD8+ T cells, progenitor exhausted CD8+ T (Tpex) cells, has been identified. These Tpex cells are notable for their remarkable self-renewal and rapid proliferation abilities. Recent strides in immunotherapy have demonstrated that Tpex cells expand and differentiate into responsive exhausted CD8+ T cells, thus underscoring their critical role in the immunotherapeutic retort. Clinical examinations have further clarified a robust positive correlation between the proportional abundance of Tpex cells and enhanced clinical prognosis. Tpex cells have found noteworthy applications in the formulation of inventive immunotherapeutic approaches against tumors. This review describes the functions of Tpex cells in the tumor milieu, particularly their potential utility in tumor immunotherapy. Precisely directing Tpex cells may be essential to achieving successful outcomes in immunotherapy against tumors.

引用

页码：499 / 512

页数：14

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