Impact of microbiome modulation on serum cytokine profile in a randomized, phase I trial of cabozantinib/nivolumab (cabo/nivo) with or without CBM588 in pts with metastatic renal cell carcinoma (mRCC)

被引：0

作者：

Li, Yu Jun ^{[1
]}

Ebrahimi, Hedyeh ^{[2
]}

Meza, Luis ^{[2
,3
]}

Malhotra, Jasnoor ^{[2
]}

Li, Xiaochen ^{[4
]}

Dizman, Nazli ^{[2
,5
]}

Dorff, Tanya ^{[2
]}

Frankel, Paul ^{[4
]}

Llamas-Quitiquit, Marian ^{[2
]}

Hsu, JoAnn ^{[2
]}

Zengin, Zeynep ^{[2
,3
]}

Alcantara, Marice ^{[2
]}

Castro, Daniela ^{[2
]}

Mercier, Benjamin ^{[2
]}

Chawla, Neal ^{[2
]}

Chehrazi-Raffle, Alexander ^{[2
]}

Barragan-Carrillo, Regina ^{[2
]}

Gillece, John ^{[6
]}

Trent, Jeffrey ^{[6
]}

Lee, Peter ^{[7
]}

Parks, Thomas ^{[8
]}

Takahashi, Motomichi ^{[9
]}

Hayashi, Atsushi ^{[9
]}

Caporaso, J. Gregory ^{[10
]}

Lee, Keehoon ^{[10
]}

Tripathi, Abhishek ^{[2
]}

Pal, Sumanta ^{[2
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA USA

[2] City Hope Comprehens Canc Ctr, Dept Med Oncol, Duarte, CA USA

[3] Yale Univ, Sch Med, New Haven, CT USA

[4] City Hope Comprehens Canc Ctr, Dept Biostat, Duarte, CA USA

[5] Univ Texas MD Anderson Canc Ctr, Houston, TX USA

[6] Translat Genom Res Inst TGen, Phoenix, AZ USA

[7] City Hope Comprehens Canc Ctr, Dept Immunooncol, Duarte, CA USA

[8] Osel Inc, Mountain View, CA USA

[9] Miyarisan Pharmaceut Co Ltd, Tokyo, Japan

[10] Translat Genom Res Inst TGen, Flagstaff, AZ USA

来源：

ONCOLOGIST | 2024年 / 29卷

关键词：

combination therapy; microbiome; probiotic;

D O I：

10.1093/oncolo/oyae181.059

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：S36 / S37

页数：2

共 2 条

[1] Impact of CBM588 on gut microbiome composition and dysbiosis in patients receiving frontline immune checkpoint inhibitor (ICI) combinations for metastatic renal cell carcinoma (mRCC)
Dizman, Nazli
Ebrahimi, Hedyeh
Barragan-Carrillo, Regina
Meza, Luis A.
Bergerot, Paulo
Dorff, Tanya
Hsu, JoAnn
Zengin, Zeynep
Castro, Daniela
Chehrazi-Raffle, Alex
Triphathi, Abhishek
Trent, Jeffrey
Takahashi, Motomichi
Oka, Kentaro
Higashi, Seiya
Caporaso, Gregory
Lee, Keehoon
Pal, Sumanta K.
ONCOLOGIST, 2024, 29 : S6 - S6
[2] Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Dizman, Nazli
Meza, Luis
Bergerot, Paulo
Alcantara, Marice
Dorff, Tanya
Lyou, Yung
Frankel, Paul
Cui, Yujie
Mira, Valerie
Llamas, Marian
Hsu, Joann
Zengin, Zeynep
Salgia, Nicholas
Salgia, Sabrina
Malhotra, Jasnoor
Chawla, Neal
Chehrazi-Raffle, Alex
Muddasani, Ramya
Gillece, John
Reining, Lauren
Trent, Jeff
Takahashi, Motomichi
Oka, Kentaro
Higashi, Seiya
Kortylewski, Marcin
Highlander, Sarah K.
Pal, Sumanta K.
NATURE MEDICINE, 2022, 28 (04) : 704 - +

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