Dysregulated Expression Patterns of Circular RNAs in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential

被引：5

作者：

Desouza, Nicole R. ^{[1
]}

Nielsen, Kate J. ^{[1
]}

Jarboe, Tara ^{[1
]}

Carnazza, Michelle ^{[1
]}

Quaranto, Danielle ^{[1
]}

Kopec, Kaci ^{[1
]}

Suriano, Robert ^{[1
,2
]}

Islam, Humayun K. ^{[1
]}

Tiwari, Raj K. ^{[1
,3
]}

Geliebter, Jan ^{[1
,3
]}

机构：

[1] New York Med Coll, Dept Pathol Microbiol & Immunol, Valhalla, NY 10595 USA

[2] Univ Mt St Vincent, Div Nat Sci, Bronx, NY 10471 USA

[3] New York Med Coll, Dept Otolaryngol, Valhalla, NY 10595 USA

来源：

BIOMOLECULES | 2024年 / 14卷 / 04期

关键词：

circular RNAs; circRNA; circRNA function; circRNA application; cancer; OVARIAN-CANCER; GASTRIC-CANCER; PROMOTES; PROGRESSION; MELANOMA; CIRCRNA; CARCINOMA; CONTRIBUTES; TRANSITION; DIAGNOSIS;

D O I：

10.3390/biom14040384

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circular RNAs (circRNAs) are stable, enclosed, non-coding RNA molecules with dynamic regulatory propensity. Their biogenesis involves a back-splicing process, forming a highly stable and operational RNA molecule. Dysregulated circRNA expression can drive carcinogenic and tumorigenic transformation through the orchestration of epigenetic modifications via extensive RNA and protein-binding domains. These multi-ranged functional capabilities have unveiled extensive identification of previously unknown molecular and cellular patterns of cancer cells. Reliable circRNA expression patterns can aid in early disease detection and provide criteria for genome-specific personalized medicine. Studies described in this review have revealed the novelty of circRNAs and their biological ss as prognostic and diagnostic biomarkers.

引用

页数：26

共 135 条

[1] CircRNAs and cancer: Biomarkers and master regulators [J].

Arnaiz, Esther ;

Sole, Carla ;

Manterola, Lorea ;

Iparraguirre, Leire ;

Otaegui, David ;

Lawrie, Charles H. .

SEMINARS IN CANCER BIOLOGY, 2019, 58 :90-99

[2] Endometrial Cancer Molecular Characterization: The Key to Identifying High-Risk Patients and Defining Guidelines for Clinical Decision-Making? [J].

Baiden-Amissah, Regina Esi Mensimah ;

Annibali, Daniela ;

Tuyaerts, Sandra ;

Amant, Frederic .

CANCERS, 2021, 13 (16)

[3] Long noncoding RNAs in cancer: mechanisms of action and technological advancements [J].

Bartonicek, Nenad ;

Maag, Jesper L. V. ;

Dinger, Marcel E. .

MOLECULAR CANCER, 2016, 15

[4] Seeing Is Believing: Visualizing Circular RNAs [J].

Bejugam, Pruthvi Raj ;

Das, Aniruddha ;

Panda, Amaresh Chandra .

NON-CODING RNA, 2020, 6 (04) :1-18

[5] Long Noncoding RNA and Cancer: A New Paradigm [J].

Bhan, Arunoday ;

Soleimani, Milad ;

Mandal, Subhrangsu S. .

CANCER RESEARCH, 2017, 77 (15) :3965-3981

[6] Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis [J].

Bian, Donghui ;

Wu, Yan ;

Song, Guodong .

BIOMEDICINE & PHARMACOTHERAPY, 2018, 108 :165-176

[7] Immunotherapy for the treatment of multiple myeloma [J].

Boussi, Leora S. ;

Avigan, Zachary M. ;

Rosenblatt, Jacalyn .

FRONTIERS IN IMMUNOLOGY, 2022, 13

[8] Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer [J].

Brahim, Sonia ;

Negulescu, Ana-Maria ;

Geneste, Clara ;

Schott, Thomas ;

Lin, Shuheng ;

Morel, Louis-Oscar ;

Rama, Nicolas ;

Gadot, Nicolas ;

Treilleux, Isabelle ;

Mehlen, Patrick ;

Meurette, Olivier .

CELL DEATH & DISEASE, 2023, 14 (02)

[9]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[10] Integrated genomic and molecular characterization of cervical cancer [J].

Burk, Robert D. ;

Chen, Zigui ;

Saller, Charles ;

Tarvin, Katherine ;

Carvalho, Andre L. ;

Scapulatempo-Neto, Cristovam ;

Silveira, Henrique C. ;

Fregnani, Jose H. ;

Creighton, Chad J. ;

Anderson, Matthew L. ;

Castro, Patricia ;

Wang, Sophia S. ;

Yau, Christina ;

Benz, Christopher ;

Robertson, A. Gordon ;

Mungall, Karen ;

Lim, Lynette ;

Bowlby, Reanne ;

Sadeghi, Sara ;

Brooks, Denise ;

Sipahimalani, Payal ;

Mar, Richard ;

Ally, Adrian ;

Clarke, Amanda ;

Mungall, Andrew J. ;

Tam, Angela ;

Lee, Darlene ;

Chuah, Eric ;

Schein, Jacqueline E. ;

Tse, Kane ;

Kasaian, Katayoon ;

Ma, Yussanne ;

Marra, Marco A. ;

Mayo, Michael ;

Balasundaram, Miruna ;

Thiessen, Nina ;

Dhalla, Noreen ;

Carlsen, Rebecca ;

Moore, Richard A. ;

Holt, Robert A. ;

Jones, Steven J. M. ;

Wong, Tina ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Kucherlapati, Raju ;

Hadjipanayis, Angela ;

Seidman, Jonathan ;

Kucherlapati, Melanie ;

Ren, Xiaojia ;

Xu, Andrew W. .

NATURE, 2017, 543 (7645) :378-+

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