Challenges and innovations in CAR-T cell therapy: a comprehensive analysis

被引:5
|
作者
Luo, Jingming [1 ]
Zhang, Xianwen [1 ]
机构
[1] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
基金
中国国家自然科学基金;
关键词
CAR-T therapy; TME; CRS; Boolean logic gate strategy; CAR-NK therapy; TUMOR-INFILTRATING LYMPHOCYTES; EFFICACY; ACTIVATION; ANTITUMOR; MICROENVIRONMENT; IMMUNOTHERAPY; PERSISTENCE; RECOGNITION; MOLECULE; MELANOMA;
D O I
10.3389/fonc.2024.1399544
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Recent years have seen a marked increase in research on chimeric antigen receptor T (CAR-T) cells, with specific relevance to the treatment of hematological malignancies. Here, the structural principles, iterative processes, and target selection of CAR-T cells for therapeutic applications are described in detail, as well as the challenges faced in the treatment of solid tumors and hematological malignancies. These challenges include insufficient infiltration of cells, off-target effects, cytokine release syndrome, and tumor lysis syndrome. In addition, directions in the iterative development of CAR-T cell therapy are discussed, including modifications of CAR-T cell structures, improvements in specificity using multi-targets and novel targets, the use of Boolean logic gates to minimize off-target effects and control toxicity, and the adoption of additional protection mechanisms to improve the durability of CAR-T cell treatment. This review provides ideas and strategies for the development of CAR-T cell therapy through an in-depth exploration of the underlying mechanisms of action of CAR-T cells and their potential for innovative modification.
引用
收藏
页数:16
相关论文
共 50 条
  • [41] A comprehensive analysis of the fatal toxic effects associated with CD19 CAR-T cell therapy
    Cai, Changjing
    Tang, Diya
    Han, Ying
    Shen, Edward
    Ahmed, Omar Abdihamid
    Guo, Cao
    Sheng, Hong
    Zeng, Shan
    AGING-US, 2020, 12 (18): : 18741 - 18753
  • [42] CAR-T Cell Therapy for T-Cell Malignancies
    Testa, Ugo
    Chiusolo, Patrizia
    Pelosi, Elvira
    Castelli, Germana
    Leone, Giuseppe
    MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2024, 16 (01)
  • [43] Teaming up for CAR-T cell therapy
    Waesch, Ralph
    Munder, Markus
    Marks, Reinhard
    HAEMATOLOGICA, 2019, 104 (12) : 2335 - 2336
  • [44] Leukapheresis for CAR-T cell production and therapy
    Pessach, Ilias
    Nagler, Arnon
    TRANSFUSION AND APHERESIS SCIENCE, 2023, 62 (06)
  • [45] Advances in Universal CAR-T Cell Therapy
    Lin, Haolong
    Cheng, Jiali
    Mu, Wei
    Zhou, Jianfeng
    Zhu, Li
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [46] Nonlinear dynamics of CAR-T cell therapy
    Fassoni, Artur C.
    Braga, Denis C.
    CHAOS SOLITONS & FRACTALS, 2025, 191
  • [47] A Theranostic Approach for CAR-T Cell Therapy
    Weber, Wolfgang A.
    Varasteh, Zohreh
    Fritschle, Katja
    Morath, Volker
    CLINICAL CANCER RESEARCH, 2022, 28 (24) : 5241 - 5243
  • [48] Reactions Related to CAR-T Cell Therapy
    Miao, Lele
    Zhang, Zhengchao
    Ren, Zhijian
    Li, Yumin
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [49] New development in CAR-T cell therapy
    Wang, Zhenguang
    Wu, Zhiqiang
    Liu, Yang
    Han, Weidong
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2017, 10
  • [50] New development in CAR-T cell therapy
    Zhenguang Wang
    Zhiqiang Wu
    Yang Liu
    Weidong Han
    Journal of Hematology & Oncology, 10