Kidney R2*Mapping for Noninvasive Evaluation of Iron Overload in Paroxysmal Nocturnal Hemoglobinuria

被引:0
作者
Ito, Koichi [1 ]
Ohgi, Kazuyuki [1 ]
Kimura, Koichiro [1 ,2 ]
Ishitaki, Koichi [1 ,3 ]
Yamashita, Akiyoshi [1 ]
Yokote, Hiroyuki [1 ]
Tsukuda, Shunji [1 ]
Matsushita, Ko [1 ]
Naraoka, Yuko [1 ]
Fujioka, Amon [1 ]
Ono, Tatsuki [1 ]
机构
[1] Japanese Red Cross Med Ctr, Dept Radiol, 4-1-22 Hiroo,Shibuya ku, Tokyo 1508935, Japan
[2] Tokyo Med & Dent Univ, Grad Sch Med, Dept Diagnost Radiol, Tokyo, Japan
[3] Shin Yurigaoka Gen Hosp, Dept Diagnost Radiol, Kawasaki, Kanagawa, Japan
关键词
iron deposition; kidney; magnetic resonance imaging; paroxysmal nocturnal hemoglobinuria; R2*mapping; SICKLE-CELL-DISEASE; ITERATIVE DECOMPOSITION; ECHO ASYMMETRY; MRI; THALASSEMIA; ECULIZUMAB; FAT; DEPOSITION; HEMOLYSIS; WATER;
D O I
10.2463/mrms.mp.2023-0114
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: The kidney iron deposition can cause kidney damage and renal insufficiency in paroxysmal nocturnal hemoglobinuria (PNH) patients. Assessment of iron deposition in the kidney is essential for the early diagnosis of renal damage in PNH patients. The purpose of this study was to evaluate kidney R2* (T2* reciprocals) values in PNH patients using the iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ). Methods: Two radiologists measured the R2* values of the renal cortex in 14 PNH patients and 13 healthy volunteers using IDEAL-IQ. Lactate dehydrogenase (LDH), a reliable marker of intravascular hemolysis, was also measured in all participants. Results: The kidney R2* values were significantly higher in PNH patients compared with those in healthy volunteers (P < 0.001). High inter-operator reproducibility of the measurements was also acquired using IDEAL-IQ. LDH levels were also significantly higher in PNH patients compared with those in healthy volunteers (P < 0.001). Kidney R2* values strongly correlated with LDH levels in PNH patients. Conclusion: IDEAL-IQ has a possibility of becoming a useful method for the noninvasive evaluation of renal iron overload in PNH patients.
引用
收藏
页码:204 / 209
页数:6
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