The Effect of the Angiotensin-Converting Enzyme Inhibitor Perindopril on the Lipid Status of Rattus Norvegicus (Berkenhout 1769)

Angiotensin-converting enzyme (ACE) inhibitors are an important group of drugs that are widely used in the treatment of hypertension and congestive heart failure. Perindopril is an ester-inactive form of the angiotensin-converting inhibitor perindoprilat. Compared to other an- giotensin-converting enzyme inhibitors, perindopril has a higher affinity and lipophilicity. The aim of this work was to investigate the effect of the angiotensin-converting enzyme inhibitor, perindopril, on the lipid status of Rattus norvegicus (Berkenhout 1769), Wistar strain. After four days of subcutaneous application of perindopril in individuals of the species Rattus norvegicus, changes in the concentration of the investigated parameters were recorded. The individuals were divided into two experimental groups of 10 individuals each. Individuals of the first experimental group were administered an aqueous solution of perindopril at a concentration of 0.8 mg/kg, while individuals of the second experimental group were administered perindopril at a concentration of 1.6 mg/kg of body weight. By mutual comparison of the results obtained between the two experimental groups, it can be concluded that there was a change in the concentration of all tested parameters, and there is also a difference in the values of the tested parameters of the lipid profile in both tested groups compared to reference literature data (total cholesterol (UH) 2.95 mmol/l, triglycerides (Tg) 0.86 mmol/l, HDL-cholesterol 1.27 mmol/l, LDL-cholesterol 1.28 mmol/l and VLDL cholesterol 0.39 mmol/l, with the difference being greater in the group with a higher applied dose.