A comprehensive comparison of DNA and RNA vaccines

被引：19
作者：
Wang, Chunxi [1 ]
Yuan, Fan [1 ]
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27705 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2024年 / 210卷
基金：
美国国家卫生研究院;
关键词：
Nucleic acid vaccine; COVID-19; Infectious disease; Cancer vaccine; MESSENGER-RNA; PLASMID DNA; IN-VIVO; MINICIRCLE DNA; LIPID NANOPARTICLES; GENE-EXPRESSION; DENDRITIC CELLS; IMMUNE-RESPONSES; HEALTHY-ADULTS; OPEN-LABEL;
D O I：
10.1016/j.addr.2024.115340
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nucleic acid technology has revolutionized vaccine development, enabling rapid design and production of RNA and DNA vaccines for prevention and treatment of diseases. The successful deployment of mRNA and plasmid DNA vaccines against COVID-19 has further validated the technology. At present, mRNA platform is prevailing due to its higher efficacy, while DNA platform is undergoing rapid evolution because it possesses unique advantages that can potentially overcome the problems associated with the mRNA platform. To help understand the recent performances of the two vaccine platforms and recognize their clinical potentials in the future, this review compares the advantages and drawbacks of mRNA and DNA vaccines that are currently known in the literature, in terms of development timeline, financial cost, ease of distribution, efficacy, safety, and regulatory approval of products. Additionally, the review discusses the ongoing clinical trials, strategies for improvement, and alternative designs of RNA and DNA platforms for vaccination.
引用
收藏
页数：19
相关论文
共 234 条
[21]   When will the world get cancer vaccines? [J].
Baraniuk, Chris .
BMJ-BRITISH MEDICAL JOURNAL, 2023, 380
[22]   The clinical progress of mRNA vaccines and immunotherapies [J].
Barbier, Ann J. ;
Jiang, Allen Yujie ;
Zhang, Peng ;
Wooster, Richard ;
Anderson, Daniel G. .
NATURE BIOTECHNOLOGY, 2022, 40 (06) :840-854
[23]   Self-amplifying RNA vaccines for infectious diseases [J].
Bloom, Kristie ;
van den Berg, Fiona ;
Arbuthnot, Patrick .
GENE THERAPY, 2021, 28 (3-4) :117-129
[24]   Vector optimization and needle-free intradermal application of a broadly protective polyvalent influenza A DNA vaccine for pigs and humans [J].
Borggren, Marie ;
Nielsen, Jens ;
Bragstad, Karoline ;
Karlsson, Ingrid ;
Krog, Jesper S. ;
Williams, James A. ;
Fomsgaard, Anders .
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2015, 11 (08) :1983-1990
[25]   Reduction of plasmid vector backbone length enhances reporter gene expression [J].
Boye, Carly ;
Arpag, Sezgi ;
Francis, Michael ;
DeClemente, Scott ;
West, Aislin ;
Heller, Richard ;
Bulysheva, Anna .
BIOELECTROCHEMISTRY, 2022, 144
[26]   The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer [J].
Bros, M ;
Ross, XL ;
Pautz, A ;
Reske-Kunz, AB ;
Ross, R .
JOURNAL OF IMMUNOLOGY, 2003, 171 (04) :1825-1834
[27]   Biomaterials for intranasal and inhaled vaccine delivery [J].
Cahn, Devorah ;
Amosu, Mayowa ;
Maisel, Katharina ;
Duncan, Gregg A. .
NATURE REVIEWS BIOENGINEERING, 2023, 1 (02) :83-84
[28]   mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations [J].
Carreno, Juan Manuel ;
Singh, Gagandeep ;
Tcheou, Johnstone ;
Srivastava, Komal ;
Gleason, Charles ;
Muramatsu, Hiromi ;
Desai, Parnavi ;
Aberg, Judith A. ;
Miller, Rachel L. ;
Pardi, Norbert ;
Simon, Viviana ;
Krammer, Florian .
VACCINE, 2022, 40 (42) :6114-6124
[29]   Current Progress in Electrotransfection as a Nonviral Method for Gene Delivery [J].
Cervia, Lisa D. ;
Yuan, Fan .
MOLECULAR PHARMACEUTICS, 2018, 15 (09) :3617-3624
[30]   Role of specific endocytic pathways in electrotransfection of cells [J].
Chang, Chun-Chi ;
Wu, Mina ;
Yuan, Fan .
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2014, 1 :14058
12345678910