Live Attenuated Vaccines against Tuberculosis: Targeting the Disruption of Genes Encoding the Secretory Proteins of Mycobacteria

被引：1
作者：
Veerapandian, Raja [1 ]
Gadad, Shrikanth S. [2 ]
Jagannath, Chinnaswamy [3 ,4 ]
Dhandayuthapani, Subramanian [1 ]
机构：
[1] Texas Tech Univ, Ctr Emphasis Infect Dis, Paul L Foster Sch Med, Dept Mol & Translat Med,Hlth Sci Ctr El Paso, El Paso, TX 79905 USA
[2] Texas Tech Univ, Paul L Foster Sch Med, Dept Mol & Translat Med, Ctr Emphasis Canc,Hlth Sci Ctr El Paso, El Paso, TX 79905 USA
[3] Houston Methodist Res Inst, Dept Pathol & Genom Med, Houston, TX 77030 USA
[4] Weill Cornell Med Coll, Houston, TX 77030 USA
来源：
VACCINES | 2024年 / 12卷 / 05期
关键词：
tuberculosis; live attenuated vaccines (LAVs); gene knockout; Mycobacterium tuberculosis; BCG; secretory antigens; BACILLUS-CALMETTE-GUERIN; CELL-WALL; VII SECRETION; PHAGOSOME MATURATION; EIS PROTEIN; IN-VITRO; SUPEROXIDE-DISMUTASE; GLUTAMINE-SYNTHETASE; PROTECTIVE IMMUNITY; LIPOPROTEIN RV3763;
D O I：
10.3390/vaccines12050530
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tuberculosis (TB), a chronic infectious disease affecting humans, causes over 1.3 million deaths per year throughout the world. The current preventive vaccine BCG provides protection against childhood TB, but it fails to protect against pulmonary TB. Multiple candidates have been evaluated to either replace or boost the efficacy of the BCG vaccine, including subunit protein, DNA, virus vector-based vaccines, etc., most of which provide only short-term immunity. Several live attenuated vaccines derived from Mycobacterium tuberculosis (Mtb) and BCG have also been developed to induce long-term immunity. Since Mtb mediates its virulence through multiple secreted proteins, these proteins have been targeted to produce attenuated but immunogenic vaccines. In this review, we discuss the characteristics and prospects of live attenuated vaccines generated by targeting the disruption of the genes encoding secretory mycobacterial proteins.
引用
收藏
页数：29
相关论文
共 230 条
  • [1] The ESX-5 Secretion System of Mycobacterium marinum Modulates the Macrophage Response
    Abdallah, M. Abdallah
    Savage, Nigel D. L.
    van Zon, Maaike
    Wilson, Louis
    Vandenbroucke-Grauls, Christina M. J. E.
    van der Wel, Nicole N.
    Ottenhoff, Tom H. M.
    Bitter, Wilbert
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (10) : 7166 - 7175
  • [2] Type VII secretion - mycobacteria show the way
    Abdallah, M. Abdallah
    Gey Van Pittius, Nicolaas C.
    Champion, Patricia A. DiGiuseppe
    Cox, Jeffery
    Luirink, Joen
    Vandenbroucke-Grauls, Christina M. J. E.
    Appelmelk, Ben J.
    Bitter, Wilbert
    [J]. NATURE REVIEWS MICROBIOLOGY, 2007, 5 (11) : 883 - 891
  • [3] Mycobacterial Secretion Systems ESX-1 and ESX-5 Play Distinct Roles in Host Cell Death and Inflammasome Activation
    Abdallah, M. Abdallah
    Bestebroer, Jovanka
    Savage, Nigel D. L.
    de Punder, Karin
    van Zon, Maaike
    Wilson, Louis
    Korbee, Cees J.
    van der Sar, Astrid M.
    Ottenhoff, Tom H. M.
    van der Wel, Nicole N.
    Bitter, Wilbert
    Peters, Peter J.
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 187 (09) : 4744 - 4753
  • [4] BCGABCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice
    Aceves-Sanchez, Michel de Jesus
    Barrios-Payan, Jorge Alberto
    Segura-Cerda, Cristian Alfredo
    Flores-Valdez, Mario Alberto
    Mata-Espinosa, Dulce
    Pedroza-Roldan, Cesar
    Yadav, Rahul
    Saini, Deepak Kumar
    de la Cruz, Miguel Angel
    Ares, Miguel A.
    Bielefeldt-Ohmann, Helle
    Baay-Guzman, Guillermina
    Vergne, Isabelle
    Velazquez-Fernandez, Jesus Bernardino
    Leon, Jeannette Barba
    Hernandez-Pando, Rogelio
    [J]. VACCINE, 2023, 41 (26) : 3824 - 3835
  • [5] Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis
    Aguilo, Nacho
    Gonzalo-Asensio, Jesus
    Alvarez-Arguedas, Samuel
    Marinova, Dessislava
    Belen Gomez, Ana
    Uranga, Santiago
    Spallek, Ralf
    Singh, Mahavir
    Audran, Regine
    Spertini, Francois
    Martin, Carlos
    [J]. NATURE COMMUNICATIONS, 2017, 8
  • [6] A century of BCG: Impact on tuberculosis control and beyond*
    Ahmed, Asma
    Rakshit, Srabanti
    Adiga, Vasista
    Dias, Mary
    Dwarkanath, Pratibha
    D'Souza, George
    Vyakarnam, Annapurna
    [J]. IMMUNOLOGICAL REVIEWS, 2021, 301 (01) : 98 - 121
  • [7] The Cyclic Di-GMP Phosphodiesterase Gene Rv1357c/BCG1419c Affects BCG Pellicle Production and In Vivo Maintenance
    Alberto Flores-Valdez, Mario
    de Jesus Aceves-Sanchez, Michel
    Pedroza-Roldan, Cesar
    Jazmin Vega-Dominguez, Perla
    Prado-Montes de Oca, Ernesto
    Bravo-Madrigal, Jorge
    Laval, Francoise
    Daffe, Mamadou
    Koestler, Ben
    Waters, Christopher M.
    [J]. IUBMB LIFE, 2015, 67 (02) : 129 - 138
  • [8] Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages
    Amaral, Eduardo P.
    Riteau, Nicolas
    Moayeri, Mahtab
    Maier, Nolan
    Mayer-Barber, Katrin D.
    Pereira, Rosana M.
    Lage, Silvia L.
    Kubler, Andre
    Bishai, William R.
    D'Imperio-Lima, Maria R.
    Sher, Alan
    Andrade, Bruno B.
    [J]. FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [9] The success and failure of BCG - implications for a novel tuberculosis vaccine
    Andersen, P
    Doherty, TM
    [J]. NATURE REVIEWS MICROBIOLOGY, 2005, 3 (08) : 656 - 662
  • [10] Moving tuberculosis vaccines from theory to practice
    Andersen, Peter
    Scriba, Thomas J.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2019, 19 (09) : 550 - 562
12345678910