Potential diagnostic value of high b-value computed diffusion-weighted imaging in hepatocellular carcinoma

Aim of the study: Over the past few years, diffusion-weighted imaging (DWI) has become an increasingly important diagnostic tool in the diagnosis of liver lesions. The objective of the present study was to evaluate the diagnostic benefit of high b-value computed diffusion-weighted imaging (c-DWI) compared with standard DWI in patients with hepatocellular carcinoma (HCC) and whether there is an association with microvascular invasion (MVI). Material and methods: In total, 37 patients with histopathologically confirmed HCC were retrospectively analyzed. DWI was acquired with b-values of 50, 400, and 800 or 1000 s/mm(2) on a 1.5 T magnetic resonance imaging (MRI) scanner. The c-DWI was calculated using a monoexponential model with high b-values of 1000, 2000, 3000, 4000, and 5000 s/mm(2). All high b-value c-DWI images were compared to the standard DWI in terms of volume, detectability of hepatic lesions, and image quality. Results: Regarding lesion volume and image quality there were no statistically significant differences between standard and c-DWI. HCC lesions measured on DWI images were statistically significantly larger compared to c-DWI images starting from a b value of 2000 s/mm(2) (DWI vs. c-DWI b 2000 s/mm(2): 2 cm(3) [1-12] cm(3) vs. 1 cm(3 )[0-17] cm(3), p < 0.05). Moreover, there was deterioration of image quality starting at b = 2000 s/mm2. There were no significant differences in terms of lesion signal intensity in DWI and c-DWI images. There were no differences for the DWI parameters according to MVI status. Conclusions: C-DWI images with high b-values up to b = 1000 s/mm(2) demonstrate comparable detectability of HCC compared to standard DWI. The investigated DWI parameters were not associated with MVI status. Further research is needed to evaluate the potential benefit of high b-value c-DWI.