Local Magnesium Sulfate Administration Ameliorates Nociception, Peripheral Inflammation, and Spinal Sensitization in a Rat Model of Incisional Pain

被引：2

作者：

Wen, Zhi-Hong ^{[1
,2
]}

Wu, Zong-Sheng ^{[3
]}

Huang, Shi-Ying ^{[4
]}

Chou, Tung -Lin ^{[1
]}

Cheng, Hao-Jung ^{[2
]}

Lo, Yi-Hao ^{[5
,6
]}

Jean, Yen-Hsuan ^{[7
]}

Sung, Chun -Sung ^{[3
,8
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung, Taiwan

[2] Natl Sun Yat Sen Univ, Inst Biopharmaceut Sci, Kaohsiung, Taiwan

[3] Taipei Vet Gen Hosp, Dept Anesthesiol, Div Pain Management, Taipei 112201, Taiwan

[4] Jimei Univ, Coll Ocean Food & Biol Engn, Xiamen 361021, Peoples R China

[5] Zouying Armed Forces Gen Hosp, Dept Family Med, Kaohsiung, Taiwan

[6] Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung 804201, Taiwan

[7] Pingtung Christian Hosp, Dept Orthoped Surg, 60 Dalian Rd, Pingtung 90059, Taiwan

[8] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei 112304, Taiwan

来源：

NEUROSCIENCE | 2024年 / 547卷

关键词：

magnesium sulfate; N-methyl-D-aspartate receptor; postoperative pain; NMDA RECEPTOR ANTAGONISTS; POSTOPERATIVE PAIN; INTRAVENOUS MAGNESIUM; THERMAL HYPERALGESIA; NEUROPATHIC PAIN; ACTIVATION; CORD; HYPERSENSITIVITY; ANALGESIA; RESPONSES;

D O I：

10.1016/j.neuroscience.2024.03.033

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: Postoperative pain remains one of the most common complaints after surgery, and appropriate treatments are limited. Methods: We therefore investigated the effect of the anti-nociceptive properties of magnesium sulfate (MgSO4), an N-methyl-D-aspartate (NMDA) receptor antagonist, on incision-induced postoperative pain and peripheral and central nervous system inflammation. Results: We found that local MgSO4 administration dose-dependently increases paw withdrawal latency, indicating reduced peripheral postoperative pain. Furthermore, MgSO4 inhibited the expression of interleukin-18 (IL-18) and inducible nitric oxide synthase (iNOS) and phosphorylation of the NMDA receptor NR1 subunit in injured paw tissue and significantly attenuated microglial and astrocytic activation in the ipsilateral lumbar spinal cord dorsal horn. Conclusion: Locally administered MgSO4 has potential for development as an adjunctive therapy for preventing central nociceptive sensitization.

引用

页码：98 / 107

页数：10

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