pulmonary pharmacokinetics;
drug transporters;
metabolizing enzymes;
inhalation administration;
ORGANIC CATION TRANSPORTERS;
BRONCHIAL EPITHELIAL-CELLS;
IN-VITRO METABOLISM;
HUMAN LUNG;
P-GLYCOPROTEIN;
INHALED DRUG;
RECEPTOR OCCUPANCY;
RAT LUNG;
EXPRESSION;
VIVO;
D O I:
10.3390/ijms25094671
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The past five decades have witnessed remarkable advancements in the field of inhaled medicines targeting the lungs for respiratory disease treatment. As a non-invasive drug delivery route, inhalation therapy offers numerous benefits to respiratory patients, including rapid and targeted exposure at specific sites, quick onset of action, bypassing first-pass metabolism, and beyond. Understanding the characteristics of pulmonary drug transporters and metabolizing enzymes is crucial for comprehending efficient drug exposure and clearance processes within the lungs. These processes are intricately linked to both local and systemic pharmacokinetics and pharmacodynamics of drugs. This review aims to provide a comprehensive overview of the literature on lung transporters and metabolizing enzymes while exploring their roles in exogenous and endogenous substance disposition. Additionally, we identify and discuss the principal challenges in this area of research, providing a foundation for future investigations aimed at optimizing inhaled drug administration. Moving forward, it is imperative that future research endeavors to focus on refining and validating in vitro and ex vivo models to more accurately mimic the human respiratory system. Such advancements will enhance our understanding of drug processing in different pathological states and facilitate the discovery of novel approaches for investigating lung-specific drug transporters and metabolizing enzymes. This deeper insight will be crucial in developing more effective and targeted therapies for respiratory diseases, ultimately leading to improved patient outcomes.
机构:
Univ Autonoma Estado Morelos, Fac Farm, Cuernavaca, Morelos, MexicoUniv Autonoma Estado Morelos, Fac Farm, Cuernavaca, Morelos, Mexico
Rodriguez-Fragoso, Lourdes
Luis Martinez-Arismendi, Jose
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Univ Autonoma Estado Morelos, Fac Med, Cuernavaca, Morelos, MexicoUniv Autonoma Estado Morelos, Fac Farm, Cuernavaca, Morelos, Mexico
Luis Martinez-Arismendi, Jose
Orozco-Bustos, Danae
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Univ Autonoma Estado Morelos, Fac Med, Cuernavaca, Morelos, MexicoUniv Autonoma Estado Morelos, Fac Farm, Cuernavaca, Morelos, Mexico
Orozco-Bustos, Danae
Reyes-Esparza, Jorge
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Univ Autonoma Estado Morelos, Fac Farm, Cuernavaca, Morelos, MexicoUniv Autonoma Estado Morelos, Fac Farm, Cuernavaca, Morelos, Mexico
Reyes-Esparza, Jorge
Torres, Eliseo
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机构:
Univ New Mexico, Dept Language Literacy & Sociocultural Studies, Albuquerque, NM 87131 USAUniv Autonoma Estado Morelos, Fac Farm, Cuernavaca, Morelos, Mexico
Torres, Eliseo
Burchiel, Scott W.
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机构:
Univ New Mexico, Coll Pharm, Toxicol Program, Albuquerque, NM 87131 USAUniv Autonoma Estado Morelos, Fac Farm, Cuernavaca, Morelos, Mexico
机构:
Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R ChinaTianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China
Liu, Chang-Xiao
Yi, Xiu-Lin
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Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R ChinaTianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China
Yi, Xiu-Lin
Si, Duan-Yun
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Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R ChinaTianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China
Si, Duan-Yun
Xiao, Xue-Feng
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h-index: 0
机构:
Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China
Tianjin Univ Tradit Med, Coll Chinese Meteria Med, Tianjin 300193, Peoples R ChinaTianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China
Xiao, Xue-Feng
He, Xin
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机构:
Tianjin Univ Tradit Med, Coll Chinese Meteria Med, Tianjin 300193, Peoples R ChinaTianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China
He, Xin
Li, Ya-Zhuo
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机构:
Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R ChinaTianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China
机构:
Johnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, BelgiumJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
de Zwart, Loeckie
Scholten, Martijn
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h-index: 0
机构:
Leiden Univ, Div Pharmacol, Leiden Amsterdam Ctr Drug Res, Leiden, NetherlandsJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
Scholten, Martijn
Monbaliu, Johan G.
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h-index: 0
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Johnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, BelgiumJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
Monbaliu, Johan G.
Annaert, Pieter P.
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h-index: 0
机构:
Catholic Univ Louvain, Lab Pharmaceuticotechnol & Biopharm, B-3000 Louvain, BelgiumJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
Annaert, Pieter P.
Van Houdt, Jos M.
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h-index: 0
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Johnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, BelgiumJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
Van Houdt, Jos M.
Van den Wyngaert, Ilse
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h-index: 0
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Johnson & Johnson Pharmaceut Res & Dev, Funct Genom, Beerse, BelgiumJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
Van den Wyngaert, Ilse
De Schaepdrijver, Luc M.
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h-index: 0
机构:
Johnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, BelgiumJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
De Schaepdrijver, Luc M.
Bailey, Graham P.
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h-index: 0
机构:
Johnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, BelgiumJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
Bailey, Graham P.
Coogan, Timothy P.
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h-index: 0
机构:Johnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
Coogan, Timothy P.
Coussement, Werner C.
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h-index: 0
机构:
Johnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, BelgiumJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium
Coussement, Werner C.
Mannens, Geert S.
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h-index: 0
机构:
Johnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, BelgiumJohnson & Johnson Pharmaceut Res & Dev, Global Preclin Dev, B-2340 Beerse, Belgium