pulmonary pharmacokinetics;
drug transporters;
metabolizing enzymes;
inhalation administration;
ORGANIC CATION TRANSPORTERS;
BRONCHIAL EPITHELIAL-CELLS;
IN-VITRO METABOLISM;
HUMAN LUNG;
P-GLYCOPROTEIN;
INHALED DRUG;
RECEPTOR OCCUPANCY;
RAT LUNG;
EXPRESSION;
VIVO;
D O I:
10.3390/ijms25094671
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The past five decades have witnessed remarkable advancements in the field of inhaled medicines targeting the lungs for respiratory disease treatment. As a non-invasive drug delivery route, inhalation therapy offers numerous benefits to respiratory patients, including rapid and targeted exposure at specific sites, quick onset of action, bypassing first-pass metabolism, and beyond. Understanding the characteristics of pulmonary drug transporters and metabolizing enzymes is crucial for comprehending efficient drug exposure and clearance processes within the lungs. These processes are intricately linked to both local and systemic pharmacokinetics and pharmacodynamics of drugs. This review aims to provide a comprehensive overview of the literature on lung transporters and metabolizing enzymes while exploring their roles in exogenous and endogenous substance disposition. Additionally, we identify and discuss the principal challenges in this area of research, providing a foundation for future investigations aimed at optimizing inhaled drug administration. Moving forward, it is imperative that future research endeavors to focus on refining and validating in vitro and ex vivo models to more accurately mimic the human respiratory system. Such advancements will enhance our understanding of drug processing in different pathological states and facilitate the discovery of novel approaches for investigating lung-specific drug transporters and metabolizing enzymes. This deeper insight will be crucial in developing more effective and targeted therapies for respiratory diseases, ultimately leading to improved patient outcomes.
机构:
Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430022, Peoples R ChinaHuazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430022, Peoples R China
Shi, Shaojun
Li, Yunqiao
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机构:
Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Geriatr, Wuhan 430074, Peoples R ChinaHuazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430022, Peoples R China
机构:
Washington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USAWashington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA
Thakur, Aarzoo
Yue, Guihua
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h-index: 0
机构:
Washington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USAWashington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA
Yue, Guihua
Ahire, Deepak
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h-index: 0
机构:
Washington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USAWashington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA
Ahire, Deepak
Mettu, Vijaya S.
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h-index: 0
机构:
Washington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USAWashington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA
Mettu, Vijaya S.
Al Maghribi, Abrar
论文数: 0引用数: 0
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机构:
Washington State Univ, Elson S Floyd Coll Med, Dept Biomed Sci, Spokane, WA USAWashington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA
Al Maghribi, Abrar
Ford, Kaitlyn
论文数: 0引用数: 0
h-index: 0
机构:
Washington State Univ, Elson S Floyd Coll Med, Dept Biomed Sci, Spokane, WA USAWashington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA
Ford, Kaitlyn
Peixoto, Lucia
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h-index: 0
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Washington State Univ, Elson S Floyd Coll Med, Dept Biomed Sci, Spokane, WA USAWashington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA
Peixoto, Lucia
Leeder, J. Steven
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机构:
Childrens Mercy Kansas City, Kansas City, MO USAWashington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA
Leeder, J. Steven
Prasad, Bhagwat
论文数: 0引用数: 0
h-index: 0
机构:
Washington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USAWashington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA
机构:
Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Dong, Yaqian
Gong, Linna
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机构:
Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Gong, Linna
Lu, Xianyuan
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h-index: 0
机构:
Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Lu, Xianyuan
Ye, Mingguang
论文数: 0引用数: 0
h-index: 0
机构:
Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Ye, Mingguang
Lin, Yu
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h-index: 0
机构:
Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Lin, Yu
Xie, Shuting
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h-index: 0
机构:
Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Xie, Shuting
Zhang, Jiaxing
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h-index: 0
机构:
Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Zhang, Jiaxing
Zhou, Fenghua
论文数: 0引用数: 0
h-index: 0
机构:
Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Zhou, Fenghua
Tang, Lan
论文数: 0引用数: 0
h-index: 0
机构:
Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Tang, Lan
Zou, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defects Res Prevent & Treatmen, Changsha 410008, Hunan, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Zou, Wei
Liu, Menghua
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h-index: 0
机构:
Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
机构:
Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan
China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, TaiwanAsia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan
机构:
Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South KoreaSeoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
Kim, In-Wha
Han, Nayoung
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h-index: 0
机构:
Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South KoreaSeoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
Han, Nayoung
Burckart, Gilbert J.
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机构:
US FDA, Ctr Drug Evaluat & Res, Off Clin Pharmacol, Off Translat Sci, Silver Spring, MD USASeoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
Burckart, Gilbert J.
Oh, Jung Mi
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South KoreaSeoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
机构:
RIKEN Ctr Genom Med, Lab Pharmacogenet, Yokohama, Kanagawa, JapanUniv Tokyo, Mol Med Lab, Ctr Human Genome, Inst Med Sci,Minato Ku, Tokyo 1088639, Japan
Kiyotani, Kazuma
Mushiroda, Taisei
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h-index: 0
机构:
RIKEN Ctr Genom Med, Lab Pharmacogenet, Yokohama, Kanagawa, JapanUniv Tokyo, Mol Med Lab, Ctr Human Genome, Inst Med Sci,Minato Ku, Tokyo 1088639, Japan
Mushiroda, Taisei
Nakamura, Yusuke
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Mol Med Lab, Ctr Human Genome, Inst Med Sci,Minato Ku, Tokyo 1088639, Japan
RIKEN Ctr Genom Med, Lab Pharmacogenet, Yokohama, Kanagawa, JapanUniv Tokyo, Mol Med Lab, Ctr Human Genome, Inst Med Sci,Minato Ku, Tokyo 1088639, Japan
Nakamura, Yusuke
Zembutsu, Hitoshi
论文数: 0引用数: 0
h-index: 0
机构:Univ Tokyo, Mol Med Lab, Ctr Human Genome, Inst Med Sci,Minato Ku, Tokyo 1088639, Japan