Antioxidant Response of Maternal and Fetal Rat Liver to Selenium Nanoparticle Supplementation Compared to Sodium Selenite: Sex Differences between Fetuses

被引:0
作者
Manojlovic-Stojanoski, Milica [1 ]
Borkovic-Mitic, Slavica [1 ]
Nestorovic, Natasa [1 ]
Ristic, Natasa [1 ]
Stefanovic, Radomir [2 ,3 ]
Stevanovic, Magdalena [4 ]
Filipovic, Nenad [4 ]
Stojsavljevic, Aleksandar [5 ]
Pavlovic, Sladan [1 ]
机构
[1] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Bulevar despota Stefana 142, Belgrade 11108, Serbia
[2] Univ Clin Ctr Serbia, Dept Pathol & Med Citol, Pasterova 2, Belgrade 11000, Serbia
[3] Univ Belgrade, Fac Med, dr Koste Todorovica 26, Belgrade 11000, Serbia
[4] Serbian Acad Sci & Arts SASA, Grp Biomed Engn & Nanobiotechnol, Inst Tech Sci, Kneza Mihaila 35-IV, Belgrade 11000, Serbia
[5] Univ Belgrade, Fac Chem, Innovat Ctr, Studentski Trg 12-16, Belgrade 11000, Serbia
关键词
antioxidant response; selenium nanoparticles; sodium selenite; pregnancy; fetuses; liver; histology; oxidative stress parameters; sex differences; SPRAGUE-DAWLEY RATS; GLUTATHIONE-REDUCTASE; SUPEROXIDE-DISMUTASE; ELEMENTAL SELENIUM; NANO-SE; TOXICITY; SELENOPROTEIN; PEROXIDASE; METABOLISM; BRAIN;
D O I
10.3390/antiox13070756
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To compare the effects of organic selenium nanoparticles (SeNPs, Se0) and inorganic sodium selenite (NaSe, Na2SeO3, Se4+) on the antioxidant response in maternal and fetal rat liver, pregnant females were treated with two forms of selenium (Se) at equivalent doses during gestation (0.5 mg SeNPs or 0.5 mg NaSe/kg body weight/day). Structural parameters of the liver of gravid females and their fetuses were examined in a sex-specific manner. The oxidative stress parameters superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), total glutathione (GSH) and sulfhydryl groups (SH) were established. In addition, the Se concentration was determined in the blood, liver, urine and feces of the gravid females and in the liver of the fetuses. The structure of the liver of gravid females remained histologically the same after supplementation with both forms of Se, while the oxidative stress in the liver was significantly lower after the use of SeNPs compared to NaSe. Immaturity of fetal antioxidant defenses and sex specificity were demonstrated. This study provides a detailed insight into the differences in the bioavailability of the nano form of Se compared to sodium selenite in the livers of pregnant females and fetuses.
引用
收藏
页数:21
相关论文
共 72 条
  • [61] Antioxidant status of rats' blood and liver affected by sodium selenite and selenium nanoparticles
    Urbankova, Lenka
    Horky, Pavel
    Skladanka, Jiri
    Pribilova, Magdalena
    Smolikova, Vendula
    Nevrkla, Pavel
    Cernei, Natalia
    Lackova, Zuzana
    Hedbavny, Josef
    Ridoskova, Andrea
    Adam, Vojtech
    Kopel, Pavel
    [J]. PEERJ, 2018, 6
  • [62] Male Disadvantage in Oxidative Stress-Associated Complications of Prematurity: A Systematic Review, Meta-Analysis and Meta-Regression
    Van Westering-Kroon, Elke
    Huizing, Maurice J.
    Villamor-Martinez, Eduardo
    Villamor, Eduardo
    [J]. ANTIOXIDANTS, 2021, 10 (09)
  • [63] Selenium and preeclampsia: A global perspective
    Vanderlelie, J.
    Perkins, A. V. A.
    [J]. PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, 2011, 1 (3-4) : 213 - 224
  • [64] Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life
    Varsi, Kristin
    Bolann, Bjorn
    Torsvik, Ingrid
    Eik, Tina Constanse Rosvold
    Hol, Paul Johan
    Bjorke-Monsen, Anne-Lise
    [J]. NUTRIENTS, 2017, 9 (05):
  • [65] Glutathione-Related Enzymes and Proteins: A Review
    Vaskova, Janka
    Kocan, Ladislav
    Vasko, Ladislav
    Perjesi, Pal
    [J]. MOLECULES, 2023, 28 (03):
  • [66] Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies
    Vinceti, Marco
    Mandriolic, Jessica
    Borella, Paola
    Michalke, Bernhard
    Tsatsakis, Aristidis
    Finkelstein, Yoram
    [J]. TOXICOLOGY LETTERS, 2014, 230 (02) : 295 - 303
  • [67] Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: Comparison with selenomethionine in mice
    Wang, Huali
    Zhang, Jinsong
    Yu, Hanqing
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (10) : 1524 - 1533
  • [68] Zar JH., 2013, BIOSTAT ANAL, DOI DOI 10.2307/2265725
  • [69] Comparison of short-term toxicity between Nano-Se and selenite in mice
    Zhang, ES
    Wang, HL
    Yan, XX
    Zhang, LD
    [J]. LIFE SCIENCES, 2005, 76 (10) : 1099 - 1109
  • [70] Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: Comparison with Se-methylselenocysteine in mice
    Zhang, Jinsong
    Wang, Xufang
    Xu, Tongwen
    [J]. TOXICOLOGICAL SCIENCES, 2008, 101 (01) : 22 - 31