Papillomavirus infection and male infertility: A systematic review and meta-analysis

被引:0
作者
Garolla, Andrea [1 ]
Mereu, Silvia [1 ]
Pizzol, Damiano [2 ]
Yon, Dong Keon [3 ]
Rahmati, Masoud [4 ,5 ]
Soysal, Pinar [6 ]
Ilie, Petre Cristian [7 ]
Bertoldo, Alessandro [8 ]
Trott, Mike [9 ,10 ]
Smith, Lee [11 ]
机构
[1] Univ Padua, Dept Med, Unit Androl & Reprod Med, Padua, Italy
[2] Eni, Hlth Unit, Via Emilia 1, I-20097 San Donato Milanese, Italy
[3] Kyung Hee Univ, Med Sci Res Inst, Coll Med, Ctr Digital Hlth,Med Ctr, Seoul, South Korea
[4] Lorestan Univ, Fac Literature & Human Sci, Dept Phys Educ & Sport Sci, Khorramabad, Iran
[5] Vali E Asr Univ Rafsanjan, Fac Literature & Humanities, Dept Phys Educ & Sport Sci, Rafsanjan, Iran
[6] Bezmialem Vakif Univ, Fac Med, Dept Geriatr Med, Istanbul, Turkiye
[7] Queen Elizabeth Hosp Fdn Trust, Kings Lynn, England
[8] Osped Oderzo, Dept Obtetr & Ginecol, Unit ART G Beltrame, Treviso ULSS2, Oderzo, Italy
[9] Univ Queensland, Princess Alexandra Hosp, Bldg 33, Brisbane, Qld, Australia
[10] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia
[11] Anglia Ruskin Univ, Ctr Hlth Performance & Wellbeing, Cambridge, England
关键词
sperm quality; sperm parameters; male infertility; HPV; IN-VITRO FERTILIZATION; RISK HPV DNA; SPERM INFECTION; SEMEN; IMPACT; ASSOCIATION; PREVALENCE; QUALITY; MEN; PARAMETERS;
D O I
10.1002/hsr2.70048
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background and Aims: Increasing attention is being paid to the role of human papillomavirus (HPV) in men and specifically reproduction. Growing evidence suggests an association between HPV infection with many adverse effects including the impairment of semen parameters, the increase of blastocyst apoptosis, the reduction of endometrial implantation of trophoblastic cells, as well as the increase rate of miscarriages and spontaneous preterm birth. Methods: We systematically searched PubMed/MEDLINE, Scopus, Embase, Web of Science, CINHAL, PsycINFO, and ERIC from inception to 2nd of July 2024, for studies that investigated the association between HPV infection with sperm parameters and fertility outcomes. The meta-analysis was conducted on mean data and standard deviations. Results: We included 25 studies with a total of 6942 patients. Sperm morphology was lower in HPV positive groups versus HPV negative control groups (SMD = -0.52 95% CI -0.84; -0.21; p = 0.001). Sperm motility was also significantly lower in HPV positive groups when compared to HPV negative controls (SMD = -0.82 95% CI -1.07; -0.57; p = <0.001). Sperm volume, concentration, and pH were not significantly different between the two groups. The other 15 studies included in the systematic review for which it was not possible to conduct a meta-analysis showed strong associations between HPV infection and impairment of sperm parameters, reduced couple fertility and increased risk of pregnancy loss. Conclusions: The current evidence highlights the link between HPV infection and sperm parameters, male fertility and reproductive outcomes, which has the potential to lead to a decreased couple fertility, increased risk of pregnancy loss, re-infection and increased treatment costs.
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页数:11
相关论文
共 56 条
[51]   Human Papillomavirus and Male Infertility: What Do We Know? [J].
Sucato, Arianna ;
Butta, Michela ;
Bosco, Liana ;
Di Gregorio, Leonardo ;
Perino, Antonio ;
Capra, Giuseppina .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (24)
[52]   DNA fragmentation index and human papilloma virus in males with previous assisted reproductive technology failures [J].
Tangal, Semih ;
Tasci, Yasemin ;
Pabuccu, Emre Goksan ;
Caglar, Gamze Sinem ;
Haliloglu, Ahmet Hakan ;
Yararbas, Kanay .
TURKISH JOURNAL OF UROLOGY, 2019, 45 (01) :12-16
[53]   Association between human papillomavirus infection and sperm quality: A systematic review and a meta-analysis [J].
Wang, Shangren ;
Liu, Li ;
Zhang, Aiqiao ;
Song, Yuxuan ;
Kang, Jiaqi ;
Liu, Xiaoqiang .
ANDROLOGIA, 2021, 53 (05)
[54]  
Wells GA., 2024, NEWCASTLEOTTAWA SCAL
[55]   Correlation between HPV sperm infection and male infertility [J].
Yang, Yang ;
Jia, Chan-Wei ;
Ma, Yan-Min ;
Zhou, Li-Ying ;
Wang, Shu-Yu .
ASIAN JOURNAL OF ANDROLOGY, 2013, 15 (04) :529-532
[56]  
Zhang B, 2019, INT J CLIN EXP MED, V12, P2980